I’m undergoing a series of ketamine infusions for treatment-resistant depression. It’s a series of 6 sessions over the course of several weeks. 1-2 sessions per week.
I had my first infusion on Wednesday for an hour and it was certainly trippy. I listened to soft rock in a completely new way.
I was kind of hoping that effects would begin to take place soon after the infusion. Relief can start to take place within an hour of the first treatment. While I was not depressed or suicidal, I was not happy. In fact, I was irritable. Angry. My doctor and I are on guard to ensure that the ketamine doesn’t trigger mania since I actually have bipolar disorder and not unipolar depression. At this point, I feel like mania would be an improvement.
I’m already pessimistic about the treatment even though my doctor says it can take 3-5 infusions for relief to kick in. My next infusion is Monday. Well, there’s one thing: If I ever wondered whether I’d like doing drugs recreationally, I’ve gotten my answer by getting it legally. (That’d be a no.)
Suicides in Japan have decreased in light of the COVID-19 lockdown. According to The Guardian, “the suicide rate in Japan fell by 20% in April compared with the same time last year, the biggest drop in five years.” The stay-at-home mandates affected about 40% of suicide prevention organizations that shut down or reduced workers’ hours. Also seeming to contribute to this drop includes the lack of commuting vs many people working long hours in the office.
The latest star to reveal that she’s suffered from depression and contemplated suicide is LeAnn Rimes. In an interview with Entertainment Tonight, Rimes confesses to cheating on her husband and admits that she had thoughts about taking her own life during the ordeal. According to the UK’s Daily Mail, the 30-year-old country singer checked into a health facility to deal with anxiety and stress after being criticized for her affair.
Ebselen, an experimental bipolar disorder drug, has been found by British researchers to work like lithium but without lithium’s side effects. In mice. In testing, mice that were somehow made manic with “small doses of amphetamine” were placated with ebselen. Researchers are now moving on to testing on healthy human volunteers before studying those suffering with bipolar disorder.
According to Time magazine, ketamine—a drug that induces hallucinations and other trippy effects—may hold potential as an antidepressant.
And now scientists report on two formulations of drugs with ketamine’s benefits, but without its consciousness-altering risks, that could advance the drug even further toward a possible treatment for depression.
Ketamine is seen as a fast-acting antidepressant for those at high risk for suicide. GLYX-13, mentioned here previously, is a ketamine-like antidepressant currently in clinical trials. AstraZeneca has AZD6765, a “ketamine mimic” that does not appear to be as effective as actual ketamine.
It finds that women with symptoms of depression were 2.5 times more likely to have experienced domestic violence over their lifetimes than those in the general population, while those with anxiety disorders were more than 3.5 times more likely to have suffered domestic abuse. The extra risk grew to seven times more likely among those with post-traumatic stress disorder.
“From our study, we don’t find any reason to stop taking your medication, because untreated depression may be harmful for the pregnancy and the baby,” [Dr. Olof Stephansson, the lead author of the new report] told Reuters Health.
Finally, “gender identity disorder” has been removed from the DSM-V and has been replaced by “gender dysphoria,” a condition in which people are concerned about their gender identity. “Gender identity disorder” seemed to stigmatize gays, lesbians, and transgender individuals. The continuing inclusion of “gender dysphoria,” however, ensures that people suffering with gender identity disorder still have access to health care treatment. (In my opinion, the renaming of “gender identity disorder” to “gender dysphoria” is really a politically correct change. Homosexuality was removed from the DSM back in 1973.)
Researchers report that conflicts about personal space and property, such as borrowing items without asking and hanging around when older siblings have friends over, are associated with increased anxiety and lower self-esteem in teens a year later. And fights over issues of fairness and equality, such as whose turn it is to do chores, are associated with later depression in teens.
I’d like to tell these siblings to get over it, but I don’t have any siblings of my own to relate my experience to.
PBS’s Frontline reports that most soldiers who commit suicide have never seen combat or even been deployed. According to the Defense Department, the Army has the sharpest rate of suicides of all the military branches. About 53 percent of military personnel who took their lives in 2011 had no history of deployment to active combat zones such as Iraq or Afghanistan. Even more troubling is that 85 percent of those who committed suicide may have been deployed but not involved in direct combat. Even though the military has invested $50 million to study mental health and suicide, a stigma of getting help still remains. It seems as though military personnel would rather take their own lives than seek help.
An antidepressant called GLYX-13, currently under study, appears to work within hours and last for up to a week. The lead researcher reports little to no side effects on the drug, which is injected intravenously. The drug is in phase 2, which means that its effectiveness and safety are still being tested. I have my doubts about an intravenous drug. If doctors are not currently testing patients’ serotonin levels, how would they be able to prescribe an intravenous antidepressant?
Asthma had been the largest contributor to YLDs (years lived with disabilities) for youths in that age range in the US and Canada in 1990, but the study published in The Lancet on Thursday led by researchers at the Institute of Health Metrics and Evaluation (IHME) at the University of Washington, Seattle showed that in this group depression surpassed asthma to claim the number one spot in 2010.
Back in the 1990s, depression was not widely regarded or evaluated among teens. It was still “suck it up” and “pull yourself up by your bootstraps.” My depression was viewed as laziness or “senioritis” among my teachers. I had no sympathy and very little leeway. Now, mental health is being taken more seriously for teens, and I think that’s a good thing.
Anxiety. Depression. Suicidal thoughts. They are all rolled up in one.
I am anxious about a lot of things these days. From something as mundane as sitting here typing on the computer to driving to cold calling a prospective client (which may never pan out because I’m too anxious to call right now). My anxiety has been debilitating in the past where I didn’t want to leave my home, and I fear it’s getting to the point of debilitation again on some days.
My anxiety depresses me. It keeps me from doing things that no one would think twice about. But here I sit, a prisoner in my own body, freaking out about nearly everything. To escape this, combined with my severe lethargy, I crawl into bed and sleep, hoping that when I wake up, things will be better. But they usually are not.
Please don’t get me wrong. I have a life many people would envy: a loving husband, a supportive family, and a steady job. I am thankful for the good things in my life. But this attitude of thankfulness and gratefulness doesn’t take away the depression inside of me.
I do not want to go back to the hospital. If I fear anything worse than death, it may be going back to a psych hospital. I have passing suicidal thoughts about hanging myself, but I haven’t been able to act upon it. I can’t determine whether I am a harm to myself in which case I would need to go to the hospital. The point of the hospital (for me) is to get me away from things that would cause immediate harm to myself. But I can’t be locked up in a hospital forever. (I guess I could in a state institution but that would be a nightmare.)
Somehow, existing in this jumbled mix is me. Somewhere inside, I am bubbly, wonderfully wacky, and beautifully strange. The depression and anxiety fuzz all of that. I am only some of what I used to be. I go to sleep, hoping for some kind of reprieve from this dark cloud that hangs over me.
On February 1, 2012, Los Angeles police declared “Soul Train” legend Don Cornelius dead of an apparent self-inflicted gunshot wound. As my Facebook feed filled up with R.I.P. Don Cornelius, I thought to myself, We’re not addressing the larger issue here: how he died.
It got me thinking about suicide rates among the black community. Suicide is something largely not spoken of among black people. No one likes to discuss suicide after someone’s self-inflicted death, but I think it’s important to address the issue. A study released in 2006 showed that each year 70,000 black people try to kill themselves and about 1.4 million or 4 percent attempt suicide at least once in their lives. From an article in the Associated Press:
While depression is strongly tied to suicidal behavior in whites, anxiety disorders were more common than depression in blacks who attempted suicide in the study. That is an important racial difference that could alert doctors to black patients who might be contemplating suicide, said [Dr. Alvin Poussaint, a Harvard University psychiatry professor and race relations specialist].
According to an article that appeared in the Journal of Black Psychology:
Historically, suicidal behaviors among African Americans received scant attention because of the belief that very few African Americans completed suicide; it was also assumed that they did not experience depression. Blacks were historically viewed as a psychologically unsophisticated race that were naturally high spirited and unburdened with a sense of responsibility.
Suicide rates among black men are growing. A 2007 statistic from the National Institute of Mental Health shows that of every 100,000 people ages 65 and older, 14.3 percent of them are likely to kill themselves. Mr. Cornelius was 75.
There’s no indication that Mr. Cornelius let anything on to family or friends. In a Washington Post article, Rev. Jesse Jackson noted that Mr. Cornelius did not seem upset when they spoke a few days prior to Mr. Cornelius’s death. Police say that Mr. Cornelius left no suicide note and are investigating his mental state. They have ruled out a homicide.
A quick snapshot toward the end of Mr. Cornelius’s life shows that he had serious health issues and may have endured a bitter divorce with his second wife. This information doesn’t provide definitive proof that Mr. Cornelius was contemplating suicide, however, it may give us a peek at what may have contributed to his suicide.
Significant health issues are often overlooked in regard to a person’s mental state. Sometimes, a person won’t let on how much pain he or she may be in even though the pain may be unbearable. Mr. Cornelius may have been very lonely and in a lot of physical pain. Those two factors combined may have led him to take his life. But I am speculating—no one knows that for sure.
People will wonder how this unfortunate act could have been prevented. Unfortunately, it couldn’t. Mr. Cornelius did not tell anyone that he was depressed (as far as the media and police know), suffering, or contemplating taking his life. Generally, people most determined to take their own lives will not speak of it to anyone.
But there is a lesson to be learned here. We can encourage people of all races to speak to someone when life gets to be overwhelming and too burdensome. We don’t need anyone else who is blessed with gifts and talents to commit suicide because he or she feels as though no one will listen and no one cares. 1-800-273-8255 or 1-800-SUICIDE are good resources with people who will listen and genuinely care. May we all learn from Mr. Cornelius’s lesson and get help when we truly need it.
Although I’m not a fan of the Dexter books or TV series, I’ve been introduced to both by way of my husband who enjoys both forms of Dexter media.
The other day I flipped through Jeff Lindsay’s latest, Dexter Is Delicious, and read a little bit about the part of Dexter that he calls his “Dark Passenger,” the voice inside of him that compels him to kill. (But he justifies this by killing murderers. An interesting twist on the anti-hero.)
I ruminated on this as I’ve been dealing with a lot of suicidal thoughts lately. And really, there’s nothing wrong in my life that would cause these suicidal thoughts to arise. It’s just something in me gone haywire. It’s like a part of me that’s not really a part of me that I can kind of talk back to. It sounds otherworldly and crazy.
So I’ve taken to calling the suicidal voice (unlike Dexter’s homicidal one) in my head the “Dark Passenger.” My husband kind of likes this too as it identifies something that’s not really me although it’s a part of me.
The Dark Passenger is pretty random these days. Even if I have a slight mood crash, he’ll—because my sinister voice is clearly not a seductive she, maybe androgynous—tell me that life is not worth living and to go kill myself.
Me: What? Dark Passenger: Go kill yourself. Life isn’t worth living anyway. You’re a total failure and you know you can’t do anything right. Me: Um, why are you bugging me? I’m not even depressed right now.
Dark Passenger: [silence]
Yeah, that’s pretty much how our conversations go. It probably sounds a bit schizophrenic or something but that’s basically my stupid battle to stay alive. You can probably imagine how terrible our conversations are when I am depressed.
My Dark Passenger’s a bit starved, you see, because I haven’t tried to kill myself in a while and he’s getting antsy. I was last hospitalized for a suicide attempt in 2006 and even though I’ve had a few half-hearted attempts since or serious thoughts about an attempt, I haven’t had a serious attempt that has required me to be locked away for a good bit of time. I still get freaked out about my near-sexual assault encounter and that’s done a good job of keeping me in check for now.
So the Dark Passenger tries to get me whenever he thinks he’s got an opening:
No one signed up for your class. You’re a loser. Go kill yourself.
She never called you back. See? No one likes you. Go kill yourself.
You can’t get pregnant or do anything right. You’re not cut out to be a mother. In fact, you weren’t meant to be one because you need to go kill yourself.
And on and on and on. It’s easy to tell him to shut up when I’m not deeply depressed. Not so much otherwise.
Maybe there’s something to that “Get behind me, Satan” stuff after all. D. Martyn Lloyd-Jones, a famous British preacher, once suggested in his book Spiritual Depression to “talk back” to one’s negative voices. While it doesn’t work in the most severe of cases for me, it works. . . for the most part.
I struggled, wrestled, and prayed. A thank you to those who also prayed for me.
I poured a 3-oz cup full of Tilex and debated on drinking it. The main reason that kept me from ingesting is I wasn’t sure whether it would just cause a really bad stomach ache or whether I could actually die from it. A Google search for “Could Tilex kill you?” yielded no relevant results except for “Tilex kills mold!”
I’m happy to announce our sink drain no longer suffers mold or mildew as of this present time.
And it’s not a suicide attempt because I never attempted.