Loose Screws Mental Health News

Surprise, surprise — the likelihood of suicide attempts increases with antidepressants.

     “Suicidal patients taking antidepressants have a ‘markedly increased’ risk of additional suicide attempts but a "markedly decreased" risk of dying from suicide, a large Finnish study has found.
     “The research into nearly 15,400 patients hospitalized for suicide attempts between 1997 and 2003 showed that ‘current antidepressant use was associated with a 39 percent increase in risk of attempted suicide, but a 32 percent decrease in risk of completed suicide and a 49 percent reduced risk of death from any cause,’ the authors wrote in a report published in the Dec. 4 issue of Archives of General Psychiatry.
      “The Finnish study analyzed 15,390 suicidal patients of all ages for an average of 3.4 years. The authors said they did this ‘because previous suicide attempts are the most important risk factor for predicting suicide.’”

I think 15,390 patients is a sizeable, significant study that could probably yield semi-accurate statistics.

      “Among the 7,466 males and 7,924 females examined, there were 602 suicides, 7,136 suicide attempts requiring hospitalization and 1,583 deaths recorded during follow-up. The risk of completed suicide was 9 percent lower among those taking any antidepressants than among those not taking antidepressants.
     “But the picture was not so bright for all those who took SSRIs. It was for those taking fluoxetine (Prozac), who had a 48 percent lower risk of suicide than those not taking medication. But the study found that those taking another SSRI, venlafaxine hydrochloride (Effexor XR), had a 61 percent increased risk.”

So Prozac is better than Effexor XR in terms of suicidal risk. Nice, considering that I've had a 10-year history of suicidal attempts and this study seems to show that venlafaxine increases the risk of suicide attempts. Perhaps Effexor should be prescribed to those who aren't/have never been suicidal?

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FDA expands black-box warning on antidepressants

Black Box Warning

Muy importante:

“A Food and Drug Administration advisory panel on Wednesday agreed with the agency’s proposal that the labels on antidepressants should be expanded to include the risk of increasing suicidal thoughts and behaviors in young adults.”

This FDA expansion ruling is significant because it expands the black-box warning from children and adolescents (up to 18 years old) to young adults (up to 25 years old). However, what about the gap between those 25-34 years old? And then 34-65 years old? Studies consistently show that teens and the elderly are at the highest risk for suicide attempts. Why isn’t there also a black-box warning for those 65 and older?

My recommendation? The FDA needs to slap a general black-box warning on all antidepressants saying that it “can increase the risk of suicidal thoughts and behaviors.” Period.

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