November 21, 2011 at 1:35 pm (Anticonvulsants, Antipsychotics, Medicine/Meds)
Tags: Abilify, Aripiprazole, Lamictal, lamotrigine, medication, postamonth2011, psych drugs, side effects
Images from rxlist.com & drugs.com
Here’s a list of the side effects I’ve experienced recently taking Lamictal and Abilify (I can’t attribute any side effect to a specific drug since I am taking both):
1. Somnolence (I am sleepy within minutes after taking the drugs.)
3. Tremors (At night, I think I’m having convulsions but my husband says I don’t move.)
4. Delusions (I think I’m dying before I go to sleep.)
5. Disciplined sleep regimen (I wake up for the day when my alarm goes off. That’s consistently been 5:20 in the morning.)
6. Poor balance (This may be related to the dizziness and vertigo.)
I’ll add more to this list as I experience any additional side effects.
April 9, 2009 at 3:20 pm (Anticonvulsants, Antidepressants, Antipsychotics, Depression, Medicine/Meds, Mental Health/Illness, Personal, Schizophrenia)
Tags: Adverse Effects, Anticonvulsants, Antidepressants, big pharma, counseling, doctors, dopamine, drug withdrawal, drugs, escitalopram, Lamictal, lamotrigine, Lexapro, med withdrawal, medication, medication withdrawal, meds, neurotransmitters, paranoia, paranoid, patient, Pharma, pharma drugs, pharmaceutical, pharmaceutical companies, psych, psych drugs, psych meds, psychiatry, psychology, psychotropics, Schizophrenia, schizophrenic, serotonin, side effects, suicidal ideation, suicidal thoughts, Suicide, withdrawal
My brain isn’t functioning today quite honestly so my apologies if the following makes no sense whatsoever. It’s long and I ended up rambling.
Lately, I’ve been thinking about whether there are any benefits to using pharmaceutical drugs. I have blogger friends who are very much anti-pharmaceuticals anything, try to avoid drugs as much as possible but take them if necessary, or think pharmaceutical drugs are a Godsend.
I’m still trying to figure out where I stand.
Pharmaceutical companies are in the business of making money. It is not to their advantage to put out completely shoddy products that do not work. I’m sure many of them bury negative data and findings that do not shed a positive light on their drugs but if something works overall, they’ll put it out there. I don’t believe the doctors who are involved in these trials are all dirty, rotten sell-outs. Some of them are very well-meaning and honest who work to make these drugs as effective as possible. Call me naïve if you like but I just can’t bring myself to believe there are more greedy docs who skew results than there are those who are concerned with advancement.
I don’t think twice about popping Excedrin Migraine when I’ve got a painful, debilitating migraine; I have no problem taking naproxen (aka Aleve) when I’ve got menstrual cramps, and taking ibuprofen isn’t an issue if I have severe muscle pain. I don’t question the safety of these drugs. I’ve used them for so long, they’ve proven to be relatively safe for me (not everyone can tolerate those drugs) and efficacious. The safety risk of taking Excedrin Migraine sometimes outweighs the benefits of not taking it. (Note: I only speak of adults in terms of ingesting this kind of medication.I don’t believe developing bodies, such as youngsters, are able to handle medication that can significantly affect mood.)
When it comes to psych meds, I am not anti-medication. Psych meds should be taken on a case-by-case basis. There are some people who consider these meds to be a life-saver while others complain that it has made them miserable and worsened their lives. This is the gamble people take when choosing to ingest a psych med—most people don’t know that. Trouble is, most people don’t know when the stakes are high enough to take that risk.
I shouldn’t be in a position to judge anyone but when I hear people taking antidepressants based on circumstances—a job loss, failed relationship, loss of a life—I worry that it’s unnecessary. We are becoming a nation that is more reliant on “quick fixes” rather than developing coping mechanisms. It’s easier to pop a pill and dull your emotions than it is to face problems, tackle issues head on, and learn to work your way through it. Case in point: rising unemployment hasn’t slowed sales of antidepressants or sleeping pills.
- I have an aunt who was a violent paranoid-schizophrenic. She was placed in a mental institution and drugged up the wazoo. Now, she’s basically existing; the lights are on but no one’s home. The drugs have killed her. She’s alive but not really.
- My father was a non-violent paranoid-schizophrenic. It got to the point where we needed to medicate him to get him on track. The medication helped him to function “normally” but his thought processes and physical ability was significantly slowed. He once told me that he felt useless because my mother was busting her butt at work to pay for my college and he was basically an invalid because his mental illness had prevented him from being able to work. He died 4 months later. A few days after the funeral, my mom began to find his psych meds hidden all around the house. I often wonder if the drugs killed him.
- Another aunt (this is all on the paternal side of the family) also became a paranoid-schizophrenic. She was a brilliant woman who was basically reduced to moving from place to place to the point where she eventually became homeless and could not hold down a job. She disappeared for a while but during one cold winter, was found and brought into a homeless shelter. She was placed on meds and her cognitive functions returned despite the fact that her speech was sometimes garbled. She traveled the world, went on cruises and various excursions. The change was remarkable. Psych meds improved her life and saved her—the benefits of the drugs outweighed the side effects.
As I withdraw from Lamictal, I am curious to see who I am without this drug. Will my creative juices flow freely once again or are they now somewhat hindered? Will my cognitive functioning correct itself or will I forever suffer from problems? Will my short-term memory loss issues smooth out or will I still suffer from intermittent forgetfulness? I have some side effects that may remain with me for a while or perhaps forever (though I hope not) but seeing others fully recover after taking drugs for 10 times longer than I have gives me hope.
I feel the majority of my progress has come from intensive counseling and being infused with the truths as laid out in the Bible. I’d say 90% of my progress has been due to counseling. I give the meds 10%. You can tell I don’t place much stock in them. But they’ve helped to cut down on the mixed episodes.
So far, I haven’t had any suicidal thoughts are behaviors that are out of the ordinary. (Thank GOD.) I’ve been dealing with a mild depression but that stems from basing my worth based off of my career rather than any biological imbalances. The last time I suffered a severe depression, I was on Lexapro (if that tells you anything).
I’ve gotten a lot of resistance and concern from family members who question my decision to come off of the medication. They’ve seen a miraculous change in me and attribute it to being on meds. Meds aren’t a cure-all. They don’t see the counseling and shifting of thought processes going on that has helped me to develop coping mechanisms. Meds may help people “cope” but they don’t develop the tools needed to cope.
I’ve decided that I’ll probably give that Christian psychiatrist a call. My counselor recommended him and she said that he’s very neutral on meds and doesn’t shove them on anyone. I mentioned that I wasn’t sure if anyone would accept me as a patient only to lose me in the end—she insisted he wouldn’t mind. The intake cost is hefty but since I was able to temp a few days for my job this week—I’m not permanently returning, I can swing it.
Which brings me back to my position on psych meds: I said it earlier but I think it’s a case-by-case basis. In my personal life, I’ve seen the benefits outweigh the side effects and I’ve seen the side effects outweigh the benefits. And I’ve seen benefits (not necessarily beneficial) as a result of side effects. Psychiatry is the biggest medical guessing game of all medical specialties. There are no certainties, and there’s no one medication that works best for everyone. Pharmaceutical companies make it a point to put the disclaimer on the patient information sheet that they’re not exactly sure HOW these drugs work. All that stuff about serotonin, dopamine, and neurotransmitters is pure speculation when it comes to depression. You’ll have me convinced about chemical imbalances once I can get a MRI and blood test done. Until then, it’s all trial-and-error.
So if I do suffer from relapses while withdrawing from this medication and it gets to the point where I may need to be hospitalized, I’m not averse to remaining on the drug. Better to be alive and on a psych drug than dead because I was determined not to use it at risk to my safety. If I end up having to stay on the drug, the future of giving birth to children will seem a bit more uncertain.
March 26, 2009 at 10:44 am (Personal)
Tags: Adverse Effects, Lamictal, Lamictal withdrawal, lamotrigine, side effects
Last day on 100 mg, I think. I’ve been calling around to psychiatrists in my husband’s insurance network and it’s incredibly out of date despite the “Information updated on 3/22/2009” fine print. Someone’s not doing his or her job. I’m tired and don’t care to call around some more and deal with some nurse sounds pissed off for working in a “looney bin” and won’t give me a referral number.
So I’m left to my own devices for now and will be dropping down to 75 mg tomorrow. I’m just not sure I’ll find a psychiatrist who’s supportive enough to take me on as a patient only to lose me again in the end. Maybe the $400 2-hour intake with that Christian psychiatrist might be worth the money although I really balk at the cost.
In the meantime, I still am not sleeping well and have been sleeping all sorts of wacky hours. My job came back at me with an offer of more work but I declined this time. My job is to remain alert and catch errors and I am FAR from it. I don’t even feel safe driving right now. My comprehension level for anything is total and utter poop.
I’m simply alive and surviving. That’s all that can be asked from day to day, right? I’ll still make a few posts and my apologies in advance if they’re somewhat incoherent.
March 6, 2009 at 11:28 am (Adverse Effects, Blogs, Medicine/Meds, Suicide)
Tags: Adverse Effects, Effexor, Lamictal, lamotrigine, side effects, suicidal ideation, suicidal thoughts, Suicide, withdrawal, withdrawal symptoms
This is a great post from Ana on how she struggled with suicidal thoughts while tapering off of Effexor. She was a lot better about identifying this stuff than I’ve ever been. I’m linking to this because I want people to know that suicidal thoughts CAN be drug-induced. I’m well aware of that now coming off of Lamictal. No problems so far but I have struggled with it in the past when I tried to jump down from 200 mg to 150 mg.
March 5, 2009 at 4:14 pm (Personal)
Tags: Adverse Effects, drugs, Lamictal, lamotrigine, medication, meds, psych drugs, psych meds, side effects, withdrawal, withdrawal effects, withdrawal symptoms
I'm having the weirdest combo of side effects on this. I'm tired all the time, but I can't get to sleep easily no matter how hard I try. Then when I do sleep, it's craptastic and it feels like I never slept in the first place. Anyone else experienced this or heard of anyone who's experienced this? It's wearing me out and causing me to suffer from a lack of patience.
March 4, 2009 at 5:52 pm (Personal)
Tags: Adverse Effects, drugs, Lamictal, lamotrigine, medication, meds, psych drugs, psych meds, side effects, withdrawal, withdrawal symptoms
I'm down to 125 mg… I'm feeling sluggish and wiped out. I have what I call "body zaps" — basically I feel little prickles, like someone sticking a pin in my skin — that I find highly uncomfortable. (It's similar to feeling "brain zaps" or "brain shivers" throughout your body.) They mainly occur when I'm still, especially when I'm laying down in bed at night.
My sleeping schedule is also out of whack. While my body can be tired by midnight or 1 am, my brain simply will NOT shut off. My brain decides to shut down along with my body around 3 or 4 am from sheer exhaustion.
A few people have recommended I take melatonin to get back to a normal sleeping pattern, but I'm not sure whether that would be okay as I withdraw from the medication. Melatonin seems relatively harmless but right now, I can't tell what's normal with my body and what's not.
February 17, 2009 at 3:07 pm (Uncategorized)
Tags: Adverse Effects, antidepressant, Antidepressants, Daniel Carlat, Depression, desvenlafaxine, drug, Effexor, Effexor XR, estrogen therapy, generic, hormone therapy, hormones, hot flashes, medication, meds, menopausal, menopause, off-label, off-label usage, Premarin, Prempro, Pristiq, psych drugs, psych meds, psychotropic, side effects, vasomotor, venlafaxine, Wyeth
Here’s a list of compiled links providing information on Pristiq. These links include info from my blog and others.
February 17, 2009 at 1:41 pm (Uncategorized)
Tags: Adverse Effects, Effexor, Fluoxetine, Prozac, side effects, venlafaxine, withdrawal, withdrawal symptoms
I’ve compiled a list of my posts on Effexor (venlafaxine) withdrawal in chronological order. Do NOT take any of the information from these posts as official medical advice. This is based on my own experience; experiences may vary.
February 16, 2009 at 11:30 pm (Adverse Effects, Antidepressants, Depression, Medicine/Meds, Mental Health/Illness, Pharma)
Tags: acceptability, Adverse Effects, antidepressant rankings, Antidepressants, buproprion, celexa, citalopram, cognitive functioning, Cymbalta, Depression, drugs, duloxetine, effectiveness, Effexor, efficacy, escitalopram, Fluoxetine, fluvoxamine, irritability, Lexapro, luvox, medications, meds, milnacipran, mirtazapine, paroxetine, Paxil, primary care doctors, primary care physicians, Prozac, psych drugs, psych meds, psychiatry, psychotropics, rage, reboxetine, remeron, savella, Seroxat, sertraline, side effects, somnolence, Traci Johnson, venlafazine, vestra, violence, Wellbutrin, withdrawal, withdrawal effects, withdrawal symptoms, zoloft
A number of antidepressants were recently ranked in different surveys:
Zoloft and Lexapro came in first for a combination of effectiveness and fewer side effects, followed by Prozac (fluoxetine), Paxil (paroxetine), Cymbalta, and Luvox among others.
The first was efficacy — or how likely patients were to experience the desired effects of the drug.
1. Remeron (Mirtazapine)
2. Lexapro (Escitalopram)
3. Effexor (Venlafaxine)
4. Zoloft (Sertraline)
5. Celexa (Citalopram)
6. Wellbutrin (Buproprion)
7. Paxil (Paroxetine)
8. Savella (Milnacipran)
9. Prozac (Fluoxetine)
10. Cymbalta (Duloxetine)
11. Luvox (Fluvoxamine)
12. Vestra (Reboxetine)
The second was acceptability — the likelihood that a patient would continue using a drug for the duration of the study (it is generally assumed that a high ratio of patients dropping out indicates the presence of undesirable side effects for a drug).
1. Zoloft (Sertraline)
2. Lexapro (Escitalopram)
3. Wellbutrin (Buproprion)
4. Celexa (Citalopram)
5. Prozac (Fluoxetine)
6. Savella (Milnacipran)
7. Remeron (Mirtazapine)
8. Effexor (Venlafaxine)
9. Paxil (Paroxetine)
10. Cymbalta (Duloxetine)
11. Luvox (Fluvoxamine)
12. Vestra (Reboxetine)
My experience with Lexapro was a disaster and I’ve written about Zoloft’s connection with irritability and rage. Paxil’s side effects are especially rough (see Bob Fiddaman’s Seroxat page) while Effexor’s withdrawal effects proved to be significantly challgenging. Although Prozac offset Effexor’s withdrawal symptoms, it causes severe somnolence that can impair cognitive functioning. And last but not least, Cymbalta contributed to the unfortunate death of Traci Johnson who had no history of depression.
These drugs may be effective for many people but it’s still a guessing game. Dr. Mark I. Levy, quoted in ABC News’s article on the rankings, mentioned that while psychiatrists may not have much use for the rankings, he sees them as beneficial for primary care physicians. And Dr. Harold G. Koenig, a professor at Duke University Medical Center, adds:
“I would be likely to start patients on either Zoloft [because it’s cheaper] or Lexapro … Unfortunately, that is almost none of my patients. By the time they get to me [a psychiatrist], the primary-care doctors have tried Zoloft and other antidepressants, so my patient are not the “new to medication” kind of patients,” he said.
I won’t rehash my thoughts on PCPs prescribing antidepressants and other psych meds. You can read about them here.
February 13, 2009 at 3:29 pm (Bipolar Disorder, Diagnoses, Medicine/Meds, Mental Health/Illness, Personal, Suicide)
Tags: Adverse Effects, drugs, Lamictal, Lamictal withdrawal, lamotrigine, lamotrigine withdrawal, medication, meds, prescription, psych drugs, psych meds, psychiatric medication, psychiatrist, psychotropics, side effects, taper off, wean off, withdrawal, withdrawal effects
I am officially joining the ranks of those who are facing the challenge of Lamictal withdrawal.
On Wednesday, I went to see my psychiatrist with a plan to come off of Lamictal:
- 150 mg for 3 months
- 100 mg for 3 months
- 75 mg for 3 months
- 50 mg for 3 months
- 25 mg for 3 months
- 12.5 mg (depending on whether my side effects on the 25 mg are bad)
I told him that my husband and I were looking to have a child sometime next year and that I’d like to taper off of Lamictal but was open to the possibility of getting back on it should I encounter severe suicidal ideation and mixed episodes. He warned me against it and thought it was a bad idea.
He proceeded to say that it’s a maintenance medication, I have a lifelong disorder, it won’t just go away, my symptoms would probably return, I have a higher risk of attempting suicide, blah blah blah — am I aware of all these risks?
He explained people with bipolar depression after coming off of meds can actually be worse, undergo severe depressive episodes, have more suicide attempts, and yadda yadda yadda. To sum it all up, I was risking my life just to get off of Lamictal.
My pdoc was trying to scare me into staying medicated.
He then added if I really wanted to come off of my meds, I could “just stop.”
WHAT?! My eyes flew open.
He stated he’d had patients who had stopped cold turkey without a problem. According to him, anticonvulsants don’t have severe withdrawal effects.
WHAT?! His advice just flies in the face of what most doctors recommend. In fact, quitting Lamictal immediately increases the risk of seizures, which is exactly what I’m afraid of.
Philip’s experience and Gianna’s experience along with the comments on each blog are proof that many people have experienced tremendous withdrawal effects from decreasing Lamictal’s dosage. In the past, I’ve quit Paxil and Lexapro cold turkey — both with not-so-good results to put it mildly.
I insisted that I wanted to come off of it slowly so he said I could just cut my 200 mg pills in half and jump down to 100 mg and stop after 2 weeks.
For real? Two weeks, doc? I had a plan that would take me over a year and you’re reducing it to a mere two weeks? On 100 mg dosage?
Again, I insisted that I wanted to take more time. He reluctantly wrote me a 30-day prescription for 100 mg and said since I was off the medication, I had no need to see him anymore. “Good luck,” he flatly told me.
When I came home after the appointment (and a bitching session to my husband), I remembered that I’d stashed a few 150 mg pills away sometime ago after I jumped back up to 200. So as of Wednesday, my arsenal included:
- A bottle of six 150 mg pills
- A bottle twenty-five 200 mg pills
- A prescription for thirty 100 mg pills
I dropped down to the 150 mg on Wednesday and have been doing all right so far. I intend to keep myself at 150 mg (cutting the 200 mg and the 100 mg in half) for at least 2 weeks, then drop down to 75 mg for 2 weeks and then 50 mg for 2 weeks. I’m most worried about coming off of the 25 mg. This is a way more accelerated plan that I hoped for but I’ve got to work with the cards that I’m dealt.
We’ll see what happens.
January 16, 2009 at 8:18 am (Medicine/Meds, Mental Health/Illness, News)
Tags: Abilify, Adverse Effects, Antipsychotics, atypical antipsychotics, atypicals, cardiac arrest, Clozaril, drugs, FDA, Health Day, heart attack, heart failure, medication, meds, myocardial infarction, New England Journal of Medicine, New York Times, patient information, Patient Safety Information, psych drugs, psych medications, psych meds, psychotropics, Risperdal, Saphris, Seroquel, side effects, U.S News & World Report, Zyprexa
The New York Times has reported that a recent study found atypical antipsychotics, which include the friendly family of Clozaril, Abilify, Risperdal, Zyprexa, and Seroquel (maybe Saphris soon), can increase a patient’s risk of dying from cardiac arrest twofold.
The study published in The New England Journal of Medicine also concluded that the risk of death from the psychotropic medications isn’t high. However, an editorial also published in the same issue “urged doctors to limit their prescribing of antipsychotic drugs, especially to children and elderly patients, who can be highly susceptible to the drugs’ side effects.”
A U.S. News & World Report article linked to the FDA’s atypical antipsychotics page for further patient information. If you’re on an atypical, I’d recommend reading each word in the patient safety info that applies to you. Proofreaders like me shouldn’t be the only ones tortured with reading all the fine print. *winks*
January 12, 2009 at 10:49 am (Bipolar Disorder, Medicine/Meds, Mental Health/Illness, Personal, Pregnancy, Suicide)
Tags: Adverse Effects, blurry vision, drug, fatigue, Lamictal, lamotrigine, medication, meds, placebo, Pregnancy, pregnant, psych drugs, psych meds, psychiatric mediation, psychiatric meds, psychotropic meds, psychotropics, side effects, withdrawal
My husband and I are talking about expanding our family. While that sounds all well and good, I just have one issue:
For most women, they think, “Well, I want a kid” and the most they have to do is probably get off birth control. Just finish off their contraceptives, maybe feel a little nauseous, and move forward with their plans.
(sigh) Not me. If I want to do this right, it might be a good 6 months or so before I can consider trying.
Read the rest of this entry »
July 28, 2008 at 5:32 am (Adverse Effects, Antidepressants, Depression, Medicine/Meds, Pharma)
Tags: Adverse Effects, antidepressant, Antidepressants, Daniel Carlat, Depression, desvenlafaxine, drug, Effexor, Effexor XR, estrogen therapy, generic, hormone therapy, hormones, hot falshes, medication, meds, menopausal, menopause, off-label, off-label usage, Premarin, Prempro, Pristiq, psych drugs, psych meds, psychotropic, side effects, vasomotor, venlafaxine, Wyeth
Back in January 2007, I’d mentioned that Wyeth was not only seeking to market Pristiq (desvenlafaxine) for depression but also for the use of vasomotor symptoms in menopausal women.
I just learned that Wyeth produces two major menopause drugs, Premarin and Prempro, that allegedly has produced hormones causing cancer in more than 5,000 women. This added up to a loss of 40 million users and $1 billion annually.
With Effexor going generic in 2 years and the introduction of Pristiq to the market, Wyeth hopes to lure some of those customers back and net an annual $2 billion. However, serious questions linger about Pristiq’s side effects in menopausal women.
Why did two women in the study group taking Pristiq have heart attacks
and three need procedures to repair clogged arteries compared with none
taking placebo? How can Wyeth assure long term safety when 604 of the
2,158 test subjects took Pristiq for only six months and 318 for a year
or more? And what about serious liver complications seen in the studies?
Martha Rosenberg, reporting on Pristiq’s use as a menopausal drug, culled comments from CafePharma’s message boards and found one thread rife with mixed comments on the new drug. From an Anonymous commenter:
Read the rest of this entry »
June 3, 2008 at 10:24 am (Bipolar Disorder, Children, Medicine/Meds, Mental Health/Illness, News)
Tags: adolescents, Adverse Effects, bipolar, Bipolar Disorder, bipolar NOS, child, childhood bipolar disorder, Children, CLPsych, drugs, intueri, medication, meds, mental health, mental illness, Newsweek, psych drugs, psych meds, psychotropics, side effects, teenagers
CLPsych wrote a post on the "Growing Up Bipolar" Newsweek cover story. I agree with most of his points. Especially:
1. Max's problems are described by the journalist as "incurable" and as "a life sentence." It is true that the kid is likely in for a life of trouble. But stating that such difficulties are a certainty for the rest of his life? That's a little too certain and it's not based on any evidence. Show me one study that indicates that 100% of children like Max will always have a high level of psychological difficulties and essentially be unable to function independently.
The article even mentions that "Max will never truly be OK." Apparently, I just learned from my recent viewing of Depression: Out of the Shadows that diagnoses are not static.
Miracles have happened but to say that Max's future doesn't have a grim tint to it is unrealistic. Not because of his diagnoses but because of all 38 different medications that he's already been on.
By 7½, Max was on so many different drugs that Frazier and his
parents could no longer tell if they were helping or hurting him. He
was suffering from tics, blinking his eyes, clearing his throat and
"pulling his clothes like he wanted to get out of his skin," says
By the time Max had reached 8 years old, he was already showing the symptoms of side effects that can occur long-term. Tardive dyskinesia, hyperglycemia, diabetes, akathisia, neuroleptic malignant syndrome are all very real side effects that could develop in Max's teenage years and stick with him permanently. "Max will never truly be OK." Not because of his disorders but because these medications have given him a different "life sentence" — a life sentence of physical, visible afflictions in addition to the emotional and mental disorders he already struggles with.
I haven't really gotten into the child bipolar disorder conversation on this blog because
- it's such a controversial diagnosis that would require lengthy posts that I didn't have time for
- I found the entire diagnosis to be a bunch of hooey
But I will now.
Read the rest of this entry »
May 29, 2008 at 1:39 am (Medicine/Meds, Personal)
Tags: bipolar, Bipolar Disorder, depressed, Depression, doctor, experience, Lamictal, meds, new experiences, psychiatrist, side effects
"You’re the most promising person that’s walked through my doors in a long time."
So says the new psychiatrist I went to see today. It was a pretty funny visit but worthless. I’m not sure that this post will communicate that effectively.
Read the rest of this entry »
May 27, 2008 at 11:31 am (Medicine/Meds)
Tags: Allegra, allergies, allergy drug, fexofenadine, medications, meds, mixed episodes, mixed-mood, montelukast, paroniria, side effects, Singulair
Paroniria: Terrifying dreams causing sleep disturbances.
I was looking at the Allegra Web site to double-check whether my recent mixed-mood episodes might have been induced since I began taking the allergy drug regularly. (It’s not a far-fetched idea. Think Singulair.) "Sleep disturbances and paroniria" are a few of the many adverse effects listed for the drug.
May 23, 2008 at 5:16 pm (Antidepressants, Blogs, Loose Screws Mental Health News, Medicine/Meds, Mental Health/Illness, Military, Pregnancy, Suicide)
Tags: Adverse Effects, Antidepressants, birth defects, bravery, British Journal of Psychiatry, courageous, drugs, expecting, first trimester, Jordan Burnham, legislation, medication, meds, mental health, mental health parity, mental illness, moms, Montreal University, mothers, pasadena therapist, post-traumatic stress disorder, Pregnancy, pregnant, psych drugs, psych meds, PsychCentral, psychiatry, PTSD, Purple Heart, Purple Heart Award, senators, side effects, student, Suicide, suicide attempt, Ted Kennedy, VA, Veterans Administration, Wall Street Journal, women, WSJ
John Grohol at PsychCentral reports that the fate of the mental health parity bill is uncertain as its main champion, Sen. Ted Kennedy, takes a leave of absence to focus on treatment of his brain tumor. I echo John’s thoughts in hoping to see that other senators are willing to carry the torch and pass this important piece of legislation.
I came across a post from Kalea Chapman at pasadena therapist in which she linked to a WSJ article on whether veterans suffering from PTSD should be awarded the Purple Heart.
Supporters of awarding the Purple Heart to veterans with PTSD believe the move would reduce the stigma that surrounds the disorder and spur more soldiers and Marines to seek help without fear of limiting their careers.
Opponents argue that the Purple Heart should be reserved for physical injuries, as has been the case since the medal was reinstituted by Congress in 1932.
I side with the opponents. The Purple Heart should be awarded to be people who have visible evidence of bravery. With the rising number of PTSD prevalence, I’m afraid that the award would be handed out like candy. The rising number of veterans with PTSD on disability has caused enough of an issue that a Texas VA facility wanted mental health officials to stop diagnosing veterans with the condition.
Jordan Burnham, an 18-year-old student who survived a nine-story jump from a building, plans on walking at his graduation with the assistance of two canes. A family who used to attend my church knows this family and put him on my church’s prayer list. It’s a small world, after all.
Finally, it looks like expecting moms should have no fear of causing birth defects in their baby while taking antidepressants, according to a study being published in the British Journal of Psychiatry.
A research team from Montreal University studied more than 2000 pregnant women on antidepressants and discovered the drugs did not present any adverse effects. However, it sounds like they only oversaw the women while they were pregnant in their first trimester. I haven’t seen the actual study but it doesn’t seem to mention whether the women discontinued the antidepressants after the first trimester.
April 30, 2008 at 5:18 pm (Blogs, Medicine/Meds)
Tags: Adverse Effects, Effexor, side effects, venlafaxine, withdrawal, withdrawal symptoms
One woman had a near trouble-free time getting off of Effexor.
I was taking effexor for about 4 months due to having a anxiaty attack one day.
One day I just felt like I was ready to get off of them.
I started by slowly bringing down my dosage. Did that for 2 weeks. The 3rd week I stopped taking them all together.
The worst sympton I felt was the dizzy feeling, I think they call it vertigo. That lasted for up to 2 weeks after stopping the medication.
I am proud to say I am now completly effexer free, with no side affects any longer. It can be done. Just go slow !
April 14, 2008 at 10:21 pm (Adverse Effects, Antidepressants, Medicine/Meds, News)
Tags: Adverse Effects, akathisia, Christopher Pittman, CNN, drugs, FDA, grandparents, hearing, homicide, medications, meds, mental health, mental illness, murder, paroxetine, Patient Safety Information, Paxil, Pfizer, Pittman, post-marketing adverse events, psych drugs, psych meds, rage, sentence, sentencing, sertraline, side effects, Supreme Court, violence, zoloft
I’ve written about Christopher Pittman, now 19, who confessed to shooting and killing his grandparents when he was on psych meds at the age of 12. He appealed for a Supreme Court hearing but was denied, CNN reported today. He — and his defenders — appealed on the grounds that his 30-year sentence was “excessive for someone that age” and that the dosage of his antidepressants at the time (200 mg) “sent his mind spinning out of control.” Pittman was tried as an adult and, his lawyers argue, “no other inmate in the United States is serving so severe a sentence for a crime committed at such an early age.”
In previous posts here and here, I’ve questioned the link between Zoloft and violence/rage. Pittman, in 2001, had been switched to Zoloft a few days before the murder of his grandparents. However, it sounds like there had been some emotional problems in Pittman’s life that may have given prosecutors a solid case:
At the time of the crime, the boy had bounced around homes for years, experiencing a half dozen family splits and divorces after his mother had twice abandoned him as a child. She has not been in Pittman’s life for years.
Joe Pittman, the boy’s father, raised Christopher Pittman and his sister for much of their lives, but the relationship between father and son deteriorated. A state psychologist later testified this was a “young man who’d had difficulty with the adults in his life.”
On November 28, 2001, Pittman was sent home early for fighting in school and sent to bed by the grandparents. The boy claimed his “Pop-Pop” also beat him with a belt as punishment.
South Carolina prosecutors may easily have set Pittman up as a disturbed young man, which he very well may have been. But there are indications that this disturbance transcended his emotional state into his mental health:
After threatening to harm himself and suffering other emotional incidents, the boy was diagnosed as clinically depressed. His lawyers said Pittman was then given Paxil, a mild antidepressant no longer recommended for those under 18.
Just days before [shooting his grandparents], a doctor had begun prescribing Zoloft, another antidepressant. The family contends the abrupt substitution of drugs caused a bad chemical reaction, triggering violent outbursts.
At trial, a parade of psychiatrists offered conflicting testimony on whether the boy’s emotional problems excused his criminal behavior. Prosecutors called the Zoloft defense a “smokescreen.”
Juror Steven Platt later told CNN the crime appeared deliberate. “It always seemed like the defense was grasping at straws,” he said. “Just because you take prescription medicine doesn’t mean you can’t be held accountable for your actions.”
Read the rest of this entry »
March 9, 2008 at 2:56 pm (Blogs)
Tags: Abilify, antidepressant, antipsychotic, anxiolytic, atypical antipsychotics, bifeprunox, big pharma, Bipolar Blast, Blogs, brain, Bristol-Myers-Squibb, depressed, Depression, Diagnoses, diagnosis, diagnostic tests, disease, diseases, disorder, disorders, drugs, DTC, DTC advertising, Ed Silverman, Eli Lilly, Furious Seasons, Gwen Olsen, major depressive disorder, marketing, medication, meds, MRI, Olanzapine, Pharma, pharma rep, pharmaceutical companies, pharmaceutical industry, pharmaceuticals, Pharmalot, Philip Dawdy, side effects, soulful sepulcher, trial, video, weblogs, withdrawal, withdrawal symptoms, YouTube, Zyprexa
I’m catching up on reading my fellow bloggers’ posts (see Blogroll to the right), so if you’re not reading their site already, I’d encourage you to do so. Below are some posts that caught my attention. Some might be a little dated.
Gianna at Bipolar Blast: Has a video up of Gwen Olsen, an ex-pharma rep who says that pharmaceutical companies aren’t in the business of curing but in the business of "disease maintenance and symptom management." It’s nothing new but here are two quotes that caught my attention:
"And what I’m saying is provable is that the pharmaceutical industry doesn’t want to cure people. You need to understand specifically when we’re talking about psychiatric drugs in particular that these are drugs that encourage people to remain customers of the pharmaceutical industry. In fact, you will be told if you’re given a drug such as an anxiolytic, or an antidepressant, or an antipsychotic drug, that you may be on the drug for the rest of your life. And very frequently, people find that they are on the drug for a very long period of time, if not permanently, because they’re almost impossible to get off of. Some of them can have very serious withdrawal symptoms – most of them can have extremely serious withdrawal symptoms if they’re stopped cold turkey – but some people experience even withdrawal symptoms when they try to titrate or they try to eliminate the drug little by little, day after day."
"We have got to start making the pharmaceutical industry accountable for their actions and for the defective products they’re putting on the market. It won’t be long before every American is affected by this disaster and we need to be aware of what the differences are between diseases between disorders and between syndromes. Because if it doesn’t have to be scientifically proven, if there are no tests, if there are no blood tests, CAT scans, urine tests, MRIs – if there is nothing to document that you have disease, then you in fact, do not have a disease, you have a disorder and it has been given and has been diagnosed pretentiously and you need to get yourself educated and understand that there are options and those options are much more effective than drugs."
I’ve always wondered why doctors don’t run tests to diagnose any psychiatric disorders. From NIMH:
Research indicates that depressive illnesses are disorders of the brain. Brain-imaging technologies, such as magnetic resonance imaging (MRI), have shown that the brains of people who have depression look different than those of people without depression. The parts of the brain responsible for regulating mood, thinking, sleep, appetite and behavior appear to function abnormally. In addition, important neurotransmitters–chemicals that brain cells use to communicate–appear to be out of balance. But these images do not reveal why the depression has occurred.
If MRIs have shown that the people with depression have a part of the brain that functions abnormally then why isn’t it standard for all people diagnosed with depression to have an MRI done to confirm this? I have one of two hypotheses: it’s too expensive to get an MRI done for each person and that insurance won’t pay for it or the abnormal functioning cannot be detected in the brain of every depressed person. Therefore, is major depressive disorder really a made-up diagnosis?
Read the rest of this entry »
July 6, 2007 at 11:12 am (Adverse Effects, Antidepressants, Depression, Medicine/Meds, Mental Health/Illness, Pharma, Suicide)
Tags: adolescents, adults, adverse effect, aggression, agitation, AHRP, akathisia, alcohol, anger, Antidepressants, behavior, big pharma, blog, Brynn Hartman, Children, Christopher Pittman, clinical trials, comments, confidence interval, David Healy, death, Depression, drugs, dyskinesia, Eli Lilly, Fluoxetine, GlaxoSmithKline, guide, homicide, hostile, hostility, hyperkinesis, information, irritability, kids, kill, lawsuits, major depressive disorder, MDD, medications, meds, murder, OCD, patient safety, patients, pediatrics, Pfizer, pharma companies, pharmaceuticals, Phil Harman, Pittman, placebo, placebos, Prozac, psych drugs, psychiatry, psychology, rage, restlessness, Salon.com, sertraline, side effects, SSRI, studies, suicidal risk, suicidality, Suicide, teens, violence, violent, volunteers, Web site, zoloft
[This post is quite lengthy so I suggest you grab a cup of coffee or tea and sit down and read it. The following is not for the faint of heart (or those with a lack of time).]
It’s been amazing to me that I’ve received numerous comments on Zoloft inducing rage. I’m humbled by having a Pittman supporter visit my site and post some comments from the ChristopherPittman.org forums. Read the following:
In my senior year in high school I was diagnosed as being severely depressed and put on medication. The first medication that I was on I took for 5 months and it made me really aggressive. My friends and family noticed the change and I told my doctor about it and she changed my meds. After that I was fine. I am normally a very passive person and will let just about anything fly. But the medication made me really aggravated and aggressive toward my friends and family and it seemed that I wasn’t overcoming my depression. I just got done watching the 48 hours investigation on the Discovery Times Channel and felt a connection with Chris. I felt that I had to write this to let you know that Chris is not the only one out there that had these side effects. I think there should be a study done to see how many people that take antidepressants have increased aggression. The problem is that the pharmaceutical industry has deep pockets and many lobbyists. I hope this helps in some way.
I remember the case when it happened.
At the time I thought, “Zoloft right”.
Let me tell you my physician put me on Zoloft and it took about three weeks for my to become psychotic and I’m a 50 year old woman.
I have three children and I don’t make a lot of money but please let me know if I can do anything for the Pittman boy.
The jury should have been placed on Zoloft before they made they decision. Unless you’ve experience it you simply cannot believe its’ effect.
I did a bit of quick reading/research into Zoloft triggering violence in people who otherwise would have never been violent and it seems that are a few stories out there to support the assertion. I found a few comments on depressionblog.com that mentioned a link between Zoloft and rage fits. A Salon.com article published a story antidepressants inducing rage in 1999. Apparently, Brynn Hartman, the wife of famous comedian Phil Hartman, killed herself and her husband while taking Zoloft. While close friends attribute the sudden behavior on the antidepressant, others attribute it to a combination of the medication with cocaine and alcohol in her system. (Zoloft does have a warning against alcohol use in conjunction with the drug.)
One interesting thing I learned from the article is that this kind of behavior is often labeled under the name akathisia on patient safety guides. Most – if not all – of the major antidepressants list akathisia as a side effect. Here’s the initial description of this condition from Wikipedia:
Akathisia, or acathisia, is an unpleasant subjective sensation of “inner” restlessness that manifests itself with an inability to sit still or remain motionless… Its most common cause is as a side effect of medications, mainly neuroleptic antipsychotics especially the phenothiazines (such as perphenazine and chlorpromazine), thioxanthenes (such as flupenthixol and zuclopenthixol) and butyrophenones (such as haloperidol (Haldol)), and rarely, antidepressants.
Akathisia may range in intensity from a mild sense of disquiet or anxiety (which may be easily overlooked) to a total inability to sit still, accompanied by overwhelming anxiety, malaise, and severe dysphoria (manifesting as an almost indescribable sense of terror and doom).
No real mention of extreme anger or irritability mentioned there. But if you read on…
The 2006 U.K. study by Healy, Herxheimer, and Menkes observed that akathisia is often miscoded in antidepressant clinical trials as “agitation, emotional lability, and hyperkinesis (overactivity)”. The study further points out that misdiagnosis of akathisia as simple motor restlessness occurs, but that this is more properly classed as dyskinesia. Healy, et. al., further show links between antidepressant-induced akathisia and violence, including suicide, as akathisia can “exacerbate psychopathology.” The study goes on to state that there is extensive clinical evidence correlating akathisia with SSRI use, showing that approximately ten times as many patients on SSRIs as those on placebos showed symptoms severe enough to drop out of a trial (5.0% compared to 0.5%).
Read the rest of this entry »
July 3, 2007 at 6:44 am (Antipsychotics, Bipolar Disorder, Loose Screws Mental Health News, Medicine/Meds, Mental Health/Illness, Pharma)
Tags: biotech, bipolar, bipolar children, bipolar kids, CombinatoRx, companies, disease, drug makers, drugs, generics, medication, medicine, meds, NYT, payment, payola, Pharma, pharmaceutical, psychiatrists, safety, side effects
"Can an antipsychotic drug from the 1950s be paired with a 1980s antibiotic to shrink 21st-century tumors?"
That's the first line from the NYT's recent article on biotech companies mixing two unrelated generic drugs to treat medical problems. Alexis Borisy, the executive of CombinatoRx, is spearheading the movement to mix and match two different generic drugs in the hopes that the combo will cure or effectively treat a disease that may be unrelated to the drugs' initial purposes.
"Orexigen, in creating its obesity drug Contrave, took a treatment used for drug and alcohol addiction and combined it with an antidepressant sometimes used to help people quit smoking." (My guess is that the antid was Zyban.)
It's a nice concept, but I'd hate to see risk of side effects doubled. One med can be a doozy; coupled with another could turn out to be problematic.
More from the NYT: Pharmaceutical companies pay psychiatrists (to push their products) more than doctors in any other specialty.
"For instance, the more psychiatrists have earned from drug makers, the more they have prescribed a new class of powerful medicines known as atypical antipsychotics to children, for whom the drugs are especially risky and mostly unapproved."
The bipolar child paradigm.
Vermont officials disclosed Tuesday that drug company payments to psychiatrists in the state more than doubled last year, to an average of $45,692 each from $20,835 in 2005. Antipsychotic medicines are among the largest expenses for the state’s Medicaid program.
Over all last year, drug makers spent $2.25 million on marketing payments, fees and travel expenses to Vermont doctors, hospitals and universities, a 2.3 percent increase over the prior year, the state said.
The number most likely represents a small fraction of drug makers’ total marketing expenditures to doctors since it does not include the costs of free drug samples or the salaries of sales representatives and their staff members. According to their income statements, drug makers generally spend twice as much to market drugs as they do to research them.
Doesn't the last sentence make you feel all warm and fuzzy inside? It's great to know that getting people to use drugs are more important to these companies than making sure these drugs are safe to use. Yeah, yeah, I know, it's a company and companies are only out to make profits. Whatever kind of optimist is in me wants to believe that maybe there's one doctor out there who is more motivated by helping others than by pharma-backing money. But I'm only a slight optimist.
March 1, 2007 at 2:03 pm (Adverse Effects, Antidepressants, Blogs, Medicine/Meds)
Tags: Blogs, Effexor, Effexor XR, graham's blog, side effects, venlafaxine, weblogs, withdrawal, withdrawal symptoms
I really should have posted on this a LONG time ago, but Graham’s Blog has done an unbelievable job of tracking his Effexor withdrawal symptoms. Something I learned today:
"| Night Sweats – I had this very bad, constantly wake up drenched in sweat,
literally soaked to the skin and to the mattress. But Have just realised I have
not had these severity of symptoms for some weeks, which is helping with the
consistency of sleep."
Ohh, so that’s why I wake up drenched in sweat in the middle of the night regardless of whether it’s warm or cold in my room. To quote Dawdy over at Furious Seasons, like Paxil, it truly is the "gift that keeps on giving." Hooray for long-lasting effects from psych meds! [sarcasm] Now, I’ve got this occasional twitch in my cheek. I took Paxil for about 3 months in 2003 and I still get eye twitches that I never had previous to the medication.
Check out Graham’s Blog and see the hell that Effexor can cause. Stephany at soulful sepulcher tracks some helpful tips for withdrawing from a psych med.
January 23, 2007 at 12:00 am (Adverse Effects, Antidepressants, Medicine/Meds)
Tags: Atarax, brain shivers, brain shocks, dizziness, Effexor, Effexor XR, Fluoxetine, grogginess, hydroxyzine, light-headed, meds, Prozac, psych meds, side effects, sleepiness, sleepy, somnolence, venlafaxine, vertigo, withdrawal, withdrawal symptoms
I previously wrote about how fluoxetine helped smooth out my withdrawal from venlafaxine. I’m doing much better and am able to function.
What’s the update then?
I’ve got lingering side effects from either the fluoxetine or the venlafaxine – I’m not sure which.
The lingering somnolence/grogginess for about a week or so can definitely be attributed to fluoxetine. I’d never struggled with somnolence on any med except when I first started Effexor in the hospital. Grogginess has never been a problem except for my antihistamine medication hydroxyzine.
The brain shocks still linger. They’re not as bad nor are they frequent. I can walk around, turn, spin – no problem. But if I’m in the middle of walking down the street and turn my neck slightly to see if a car is coming before I cross – *zap!* – brain shock. That’s all I get for the rest of my 15-minute walk. I’d say that’s pretty good (considering what I’d previously endured).
Dizziness, vertigo, and light-headedness: those are much more frequent. As I sit here and type, my entire field of vision can swirl clockwise and return to normal via counter-clockwise. It happens for about 3 seconds or less, but it’s long enough for me to notice and go, “Whoa.” (Who needs recreational drugs when you’ve got withdrawals from psych meds?) These side effects are not as frequent as they used to be with the direct venlafaxine withdrawal, but they can occur about 30 times or less throughout a 17-hour day (7 a.m.-12 a.m.) for me.
I’ve read that people can use fluoxetine to offset venlafaxine withdrawal symptoms with relatively uneventful side effects. Somnolence was not a fun side effect. Just a warning.
January 22, 2007 at 3:14 pm (Antidepressants, Depression, Medicine/Meds)
Tags: antidepressant, clinical trials, Depression, desvenlafaxine, Effexor, Effexor XR, generic, MDD, medication, menopausal, menopause, Nausea, patent, pharmaceuticals, Pristiq, psych meds, side effects, SNRI, vasomotor, women's health, Wyeth
The Trouble With Spikol has linked to an article in the San Diego Union-Tribune (via Reuters) that covers Wyeth's new Effexor XR knock-off, Pristiq (desvenlafaxine succinate). Why are they launching Pristiq? Their patent on Effexor will expire in July 2010 when making generic versions of the drug will be up for grabs.
"Wyeth said in July, however, that it will not introduce Pristiq until it completes tests of a low 50-milligram dose of the drug, following trials of higher dosages in which about half the patients experienced nausea."
Too bad clinical trials don't test for withdrawal symptoms. Will Pristiq avoid the withdrawal hell issues that Effexor XR has?
“'We will wait for the results of the low-dose trials, which we've said we expect in early 2007, before making a decision' on when to launch Pristiq, company spokeswoman Gwen Fisher told Reuters on Friday.
She said nausea seen in the earlier trials was mild to moderate and generally went away within a week after treatment began.”
How long were these clinical trials and if the nausea was seen in the "earlier trials," what about the most recent trials?
Pending FDA approval, Wyeth would also like to use Pristiq for vasomotor symptoms in menopausal women. Wyeth's unannounced strategy will be to introduce Pristiq long before Effexor's patent expires so they don't lose any of their $1 billion market share to an Effexor generic.
A Wyeth PR that went under my radar:
“Pristiq, a serotonin/norepinephrine reuptake inhibitor (SNRI) now is being studied with a specific focus on women. It initially was developed for two indications that currently are pending approval from the U.S. Food and Drug Administration (FDA) – the treatment of major depressive disorder (MDD) and vasomotor symptoms (VMS) associated with menopause.
In the area of depression, Pristiq is expected to improve the balance of serotonin and norepinephrine as compared with serotonin reuptake inhibitors (SSRI) because of its pharmacologic profile as a dual reuptake inhibitor.”
Isn’t that what SNRIs are supposed to do?
“Clinical studies confirm that Pristiq is effective in both men and women. However, women over age 40 represent about 50 percent of the depression market and could benefit from an antidepressant that addresses their symptoms and physiology.”
No kidding – 50 percent of the depression market and the implication of all women over 40 years old? Sure, I believe that. Looks like Wall Street doesn't have much hope for the new drug either.
“Pristiq also may be a treatment option for patients who are on multiple medications. The compound has a low risk of drug-drug interactions. This is important when considering that depression often is a co-morbid condition in medically ill patients and that these patients frequently are taking multiple medications. The Company expects FDA action for the MDD indication in January 2007.”
The multiple medications thing. Um, I’m not a fan of that unless it’s absolutely necessary. It isn’t necessary in a lot of cases.
“FDA action for the second application for Pristiq for vasomotor symptoms associated with menopause is anticipated in April 2007. Pristiq is expected to provide significant relief of hot flushes (decrease in number and severity) associated with menopause.
If approved, Pristiq will be the first non-hormonal treatment indicated for relief of VMS.
The Company also plans to pursue indications for Pristiq that would include fibromyalgia syndrome and diabetic neuropathic pain.”
Wyeth certainly is attempting to milk this new drug for all it’s worth. I hope Furious Seasons or CLPsych take up on investigating this one since I simply don’t have the time, resources, or ability.
January 22, 2007 at 9:32 am (Adverse Effects, Anticonvulsants, Bipolar Disorder, Medicine/Meds, Mental Health/Illness, Pharma, Suicide)
Tags: bipolar, Bipolar Disorder, Eli Lilly, epilepsy, gabapentin, Lyrica, marketing off-label, medication, Neurontin, neuropathic pain, non-FDA approval, OCD, off-label, off-label prescription, off-label uses, Olanzapine, Parke-Davis, Pfizer, postherpetic neuralgia, pregabalin, side effects, Suicide, Warner-Lambert, Zyprexa
My mother-in-law was telling me yesterday about how her hairdresser’s daughter has been diagnosed bipolar with OCD characteristics. She says her daughter’s on “Neo-something” – she couldn’t quite remember the name.
I racked my brain for a bipolar med name that began with “n.” Nothing really came to mind except for neurontin. I told myself, “No, that can’t be right. Isn’t that associated with VNS?”
Nope; Neurontin really is a medication associated with bipolar disorder. Neurontin’s generic name is gabapentin.
Read the rest of this entry »
January 18, 2007 at 9:36 am (Adverse Effects, Antipsychotics, Bipolar Disorder, Medicine/Meds, Pharma)
Tags: Andrew J. Cutler M.D., article, AstraZeneca, atypical antipsychotic, AZ, big pharma, bipolar, bipolar depression, Bipolar Disorder, bipolar pill, Clinical Psychiatry News, clinical trial, CORE Research, Dawdy, Furious Seasons, Lamictal, lamotrigine, lithium, Patient Safety Information, pharmaceutical research, psychopharmacology, quetiapine, Seroquel, side effects, weight gain, weight loss, wikipedia
[UPDATE: I had some funky issues with my table. It should be fixed now. Sorry about that.]
The first time I visited my psychiatrist for my initial evaluation, he gave me the option of choosing one of three medications: Seroquel, Lithium, or Lamictal. He handed me information about Seroquel and Lamictal. I did some research on both meds (lithium was out of the question because I don’t have time to get my blood checked constantly) and Lamictal sounded like a way better deal than Seroquel. I found mental health blog Furious Seasons (probably via The Trouble With Spikol) and read numerous posts on Seroquel’s adverse effects and all the good stuff AstraZeneca doesn’t tell anyone. From Philip Dawdy’s “Seroquel, The Bipolar Pill?” post, here’s what stood out to me:
“He told her that he didn’t think Seroquel worked benignly for patients and that the increased blood-sugar levels and cholesterol levels associated with its use were unacceptable to him. She broke out a recent paper which claimed that there were no metabolic syndrome problems with Seroquel.”
The post got me thinking. One of the materials I received from my psychiatrist was an article on how Seroquel seems to help the depressive part of bipolar disorder. He had a stack of these articles. My guess is not that he’s an overzealous reader of various newspapers but received the glowing article from – you got it! – a pharma rep. The article was taken from the August 2005 issue of Clinical Psychiatry News. (NOTE: I received the article in November 2006.)
Clinical Psychiatry News’ publication goals:
“Clinical Psychiatry News is an independent newspaper that provides the practicing psychiatrist with timely and relevant news and commentary about clinical developments in the field and about the impact of health care policy on the specialty and the physician’s practice.”
Good thing they didn’t say objectively.
I don’t know much about ClinPsych’s reputation and whether they are generally a good paper that reports things objectively. However, the article, “Atypical Quetiapine Appears Effective for Bipolar Depression,” reads like a press release. I’m not happy about receiving (practically) PR material from my doctor when trying to make an unbiased decision.
The article’s lede:
“The atypical antipsychotic quetiapine led to significantly greater reductions in bipolar depression than did placebo within the first week of treatment and throughout an 8-week randomized, controlled study of 511 patients, Andrew J. Cutler, M.D., said.”
Dr. Cutler? Who IS Dr. Cutler? No research necessary; look no further than the article itself:
“The differences between the placebo group and each quetiapine group were significant at each weekly assessment, said Dr. Cutler of the University of South Florida, Tampa. He is a speaker and consultant for, and has received research grants from, the company that makes quetiapine: AstraZeneca.”
At least they disclosed his financial affiliations.
It is also worth noting that Dr. Cutler also founded a clinical research company, CORE Research, which runs many of the clinical trials that he’s involved in. CORE Research’s background details:
“CORE Research, Inc. is a private research company with three offices in the Central Florida area. CORE specializes in pharmaceutical research and psychopharmacology for mental illnesses such as Bipolar Disorder, Depression, Anxiety, Schizophrenia, Attention Deficit Disorder, and Insomnia.”
Private + Pharmaceutical research + Psychopharmacology = Funding from Big Pharma Companies
I sound like I’m touting some grand conspiracy theory. (OK, maybe I am.) CORE’s background bio makes the company sound objective and unaffiliated, which isn’t the case. If Dr. Cutler has “received research grants from” not only AstraZeneca, but other companies, it’s in his best interest to make sure that their pharmaceutical products turn out OK. Namely in the interest of AZ – remember: he’s a consultant for them.
How can I expect to make a decision about which medication to take (remember it’s between Lamictal and Seroquel now) based on promotional materials from pharm companies and – oh – an article touting the benefits of Seroquel with quotes only from the study’s lead author who is paid to say good things about the company’s products?
Then how did I decide on Lamictal over Seroquel? Wikipedia‘s outline of each medication’s side effects, of course, in addition to other materials. (Don’t EVER overlook the Patient Safety Information of any medication. Unless you’re reading about the molecular structure – ignore that.)
|Lamictal (lamotrigine) side effects
||Seroquel (quetiapine) side effects
|Major weight loss
||Memory problems (i.e. anterograde amnesia)
||Abnormal liver tests
|Lack of coordination
||Substantial weight gain
||Stuffy nose feeling
|Rash (Stevens-Johnson syndrome) [uncommon in adults]
||Neuroleptic malignant syndrome [rare]
|Binds to melanin-containing tissues (i.e. iris of the eye)
||Tardive dyskinesia [rare]
Not that Lamictal’s side effects looked like a walk in the park, but considering that I’d already had awful trouble with weight gain on Paxil and Lexapro – nearly 50 lbs. – Seroquel was a serious no-go on my part. That and I don’t mind major weight loss from Lamictal. (Although I have been told Lamictal has no effect on weight.) Below is a copy of the article I received from my psychiatrist or you can just go and read the archived full text at Clinical Psychiatry News.
January 14, 2007 at 10:26 pm (Adverse Effects, Antidepressants, Medicine/Meds)
Tags: active drug substance, Atarax, brain shivers, brain shocks, dizziness, dosage, electric shocks, Fluoxetine, hydroxyzine, light-headedness, Prozac, quetiapine, Seroquel, side effects, somnolence, vertigo, withdrawal, withdrawal effects
Okay, the brain shivers are gone. Completely. I still get some vertigo and light-headedness but it happens maybe three times a day max. So fluoxetine has eliminated some of the effects.
I wasn’t prepared for fluoxetine’s side effects, however. And boy, it’s got some kickers.
Since I was on an incredibly low dosage (10-20 mg), there weren’t many side effects.
But boy, is somnolence kicking my butt.
After becoming used to waking up before I’m supposed to, now I’m having the opposite problem: I can’t get up at all. I need my husband to drag me out of bed. And since he’s so nice, he doesn’t do that either.
Argh. As of Friday night, I’ve stopped taking fluoxetine so I’m praying to God that these side effects will go away. I hate somnolence. I’ve had that issue with hydroxyzine (Atarax) and it’s the same reason that I refuse to take quetiapine (Seroquel). I’m getting sleepy right now. If I can get up before noon, I’ll be so freakin’ lucky.
The metabolism aspect of fluoxetine doesn’t make me jump for joy. According to my favorite “reputable” site, wikipedia:
“Fluoxetine is metabolised to norfluoxetine, and it may take up to 1 to 2 months for the active drug substance to disappear from the body.”
I don’t know if I can tolerate somnolence for 1-2 months. I hope the side effects from this is out of my system by the end of the week.
Come to think of it: somnolence vs. brain shivers?
I’ll take somnolence ANY DAY.
January 9, 2007 at 3:32 pm (Adverse Effects, Antidepressants, Depression, Medicine/Meds, Personal)
Tags: about.com, bipolar, Bipolar Disorder, brain, brain shivers, brain shocks, Depression, discontinuation, dizziness, Effexor, Effexor XR, electric shocks, electrick shock sensations, Fluoxetine, Lamictal, lamotrigine, light-headedness, mania, manic, manic-depressive, medication, meds, paroxetine, Paxil, Prozac, psych meds, psychiatrist, quetiapine, Schimelpfening, sensory disturbances, Seroquel, side effects, symptoms, taper off, venlafaxine, vertigo, weird sensation, withdrawal, withdrawal symptoms
Work has got me busy, folks, so posts may drop significantly in the next coming days/months. Possibly through April or May. (I’ll probably have one of those work days when I end up doing more blogging than working. It happens every now and then.) But don’t be surprised if Saturday quotes, Wednesday puppies, and Sunday stats are what pops up each week. I’ve got many of those backlogged through April. I’ll try to backlog some other posts on bipolar disorder and depression for the coming weeks and quickly blog on anything that’s timely.
In the meantime, I had to take a sick day today. It’s my third day off of the Effexor and I’m having some weird side effects (see Case 1: Standard Dose under the link). Whenever I turn or move too quickly (consider your “natural” body turn), I “kind of” see stars and the whole world slightly spins beyond my field of vision for about 3 seconds before coming back into focus. After doing some light research on the side effects of venlafaxine (Effexor’s generic name), I’ve found out that side effects can incude vertigo, dizziness, light-headedness (associated with dizziness), and something called “brain shivers,” which are a form of electric shock sensations. You know that feeling when you get an electric shock from somebody? Yeah, imagine feeling that throughout your whole body. Precisely; not a good feeling. Nancy Schimelpfening, blogger for depression.about.com, found a newsgroup posting on the brain shiver effect, mainly associated with venlafaxine:
It happens to me if I turn my head quickly, or if I stop suddenly, or in general with sudden motion. They’re worse if I’m nervous.
i’ve seen them described as feeling as though your brain keeps going when you turn your head. that doesn’t seem quite adequate to me. it’s more like this:
you turn your head (or your whole body — this happens to me if i whirl around too quickly as i’m taking the stairs. what. doesn’t everyone whirl on the stairs…?), but your brain *stays put* for a micro second, then tries to catch up but only in a stuttering, stopstart motion, accompanied by a staccato ‘zzt zzt zzt’ with each stop. the ‘zzt’ you can feel in your head, an electric sort of vertigo, and it often reverberates in your hands and fingers. some folks feel it in their toes; i haven’t yet.
sometimes your brain overshoots and comes strobing back, then overshoots again.. this all unfolds in just a second or two.
these days i endeavor to go around corners all smooth slow and steadylike. helps to reduce the number of brain shivers per day
Yeah, that’s me. It’s hard to explain to someone who’s never felt it. I got this feeling after not taking Paxil for three days too. The effects eventually wore off, but it was such a weird feeling.
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December 29, 2006 at 8:19 am (Adverse Effects, Antidepressants, Blogs, Medicine/Meds)
Tags: Antidepressants, Dawdy, Furious Seasons, Lexapro, medication, meds, Paxil, psych meds, side effects, uncomfortably numb, withdrawal
Thanks to Philip Dawdy at Furious Seasons, he wrote about the Uncomfortably Numb blog. The blog focuses mainly on the side effects (and side effect withdrawals) of Paxil. Having been on Paxil (CR), I can identify. I was fortunate enough to ask my doctor for a switch after three months, but I still have this occasional eye-twitch that lasts for days that has stayed with me since taking Paxil back in February 2004. If I didn’t take Paxil for three days, my nerves just went horrible: I felt shaky and my entire life seemed fluid – it was like constantly walking in a pool of water. Nothing seemed real; everything was a dream. But it wasn’t. Everything was too hard, too much effort, too much anything. I couldn’t stand it. I quit Paxil “cold turkey” (again, don’t do this, kids) and felt worse before I could feel better. I went from Paxil to Lexapro and… yeah, felt worse again.
Lesson? Primary care physicians should NOT give antidepressants to depressed people with undiagnosed bipolar disorder.
December 18, 2006 at 11:31 am (Anxiety/Stress, Celebrities, Depression, Loose Screws Mental Health News, Medicine/Meds, Mental Health/Illness, Pharma)
Tags: antidepressant, antipsychotic, anxiety, atypical, bipolar, Bipolar Disorder, Bracco, canada.com, clinical anxiety, clinical depression, clinical trials, Depression, diabetes, Dr. Melfi, Eli Lilly, high blood sugar, hyperglycemia, Lorraine Bracco, med, medications, mental health, mental illness, New York Times, Olanzapine, psych meds, Schizophrenia, side effects, survey, The Sopranos, winter, zoloft, Zyprexa
Canada.com reports that a Canadian mental health survey found that more than 75 percent of people diagnosed with clinical anxiety or depression experience a severe relapse during the winter months, namely December and January.
“Among the symptoms those people reported, more than half said they experienced ‘feelings of worthlessness,’ ‘inappropriate guilt’ and difficulty thinking or concentrating during the winter holiday season.”
The survey also found that decreased daylight hours and increased debt during the holiday season contribute to stress among those with chronic mental illness. At least the article didn’t say there was a spike in suicides…
Lorraine Bracco, known as Dr. Melfi on The Sopranos, has written a book about her struggle with clinical depression. She notes the difference between how she functioned before her depression hit and after. She cites Zoloft as the antidepressant that helped her overcome the hump and a mental realization that she needed to get help. She no longer uses antidepressants but she feels that the antidepressant got her to a place where she could find herself again, “I found my joie de vivre, my spirit, my voice.”
And finally, it’s time to be pissed off at Eli Lilly. Documents obtained by a mental health lawyer, given to The New York Times, show that Lilly execs tried to downplay the risk of obesity and hyperglycemia in Zyprexa. The two side effects can lead to a significantly increased risk for diabetes. Lilly material even included statements to sales reps telling them to downplay those risks when pitching the atypical antipsychotic to doctors. Zyprexa, Lilly’s best-selling drug, has been sold to 2 million people and has raked in $4.2 billion worldwide. The drug is primarily prescribed for schizophrenia and bipolar disorder. Of course, Lilly execs, aware that the side effects would keep patients away from the drug, downplayed the risks and even went so far as to say, “There is no scientific evidence establishing that Zyprexa causes diabetes.”
Lawsuits speaks differently, however. Lilly has agreed to pay $750 million to 8,000 people who claim that Zyprexa has caused them to develop diabetes or other medical problems. According to the Times, “thousands more suits against the company are pending.”
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December 6, 2006 at 5:34 pm (Adverse Effects, Antidepressants, Books, Depression, Medicine/Meds, Mental Health/Illness, Personal)
Tags: Antidepressants, Breggin, Cohen, Effexor, Effexor XR, lithium, medication, meds, mental health, mental illness, psych hospital, psychiatric, psychiatrist, psychiatry, side effects, Your Drug May Be Your Problem
Originally written October 16, 2006 (Updated edits in bold red)
“So sad / so sad / sometimes she feels so sad” ~ Paul McCartney, “Another Day”
I’m finishing up my third full day in the psych hospital and I’m accomplishing things totally unrelated to my “treatment.”
I’ve gotten through 100 pages of Mark Twain’s The Adventures of Tom Sawyer. It’s an interesting book — never read it before – and reading about Tom’s mischevous ways takes me away from the dreariness of a psych hospital. I have a mind to read Huck Finn afterward.
I’m reading several books at once, however. (I’ve got ADD when it comes to books; sometimes I finish them, sometimes I don’t.) I’m finally reading my Bible again and trying to plow through Your Drug May Be Your Problem. It’s an interesting book but most of it is alarming. The authors, Breggin and Cohen, argue against psychiatric drugs completely. The books raises some awareness about the use of psychiatric drugs but I think the authors are mostly crying “Fire!” about an unattended candle. The only time I somewhat took them seriously was their discussion about lithium. I’ve already heard — and now seen — its effects. I think lithium is a drug that really shouldn’t be used any more. Are the therapeutic effects of lithium really worth risking a patient to possible toxic levels?
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