January 15, 2013 at 11:36 am (Antidepressants, Bipolar Disorder, Depression, Loose Screws Mental Health News, Medicine/Meds, Mental Health/Illness, Pharma, Suicide)
Tags: Antidepressants, Bipolar Disorder, CTE, Dave Duerson, Depression, domestic violence, ebselen, gays, gender dysphoria, gender identity disorder, Junior Seau, ketamine, lesbians, medication, mental illness, NFL, NHL, Pregnancy, Ray Easterling, soccer players, SSRI, stillbirth, Suicide, transgender
Ebselen, an experimental bipolar disorder drug, has been found by British researchers to work like lithium but without lithium’s side effects. In mice. In testing, mice that were somehow made manic with “small doses of amphetamine” were placated with ebselen. Researchers are now moving on to testing on healthy human volunteers before studying those suffering with bipolar disorder.
A study, published in JAMA Neurology, discovered that retired NFL players were more likely to suffer from depression and brain impairment. The study comes on the heels of the suicides of Dave Duerson, Ray Easterling, and Junior Seau. Researchers suspect a link between “hard hits to the head and depression.” These problems have also been noted in NHL players and combat soldiers who have suffered a brain injury. Many of the retired NFL players developed a type of brain damage called chronic traumatic encephalopathy (CTE). Duerson and Easterling were found to have CTE during autopsy. In related sports news, the UK’s Telegraph reports that depression is a problem for soccer players in England and Scotland.
According to Time magazine, ketamine—a drug that induces hallucinations and other trippy effects—may hold potential as an antidepressant.
And now scientists report on two formulations of drugs with ketamine’s benefits, but without its consciousness-altering risks, that could advance the drug even further toward a possible treatment for depression.
Ketamine is seen as a fast-acting antidepressant for those at high risk for suicide. GLYX-13, mentioned here previously
, is a ketamine-like antidepressant currently in clinical trials. AstraZeneca has AZD6765, a “ketamine mimic” that does not appear to be as effective as actual ketamine.
New research has discovered that people with mental illness are more likely to be victims of domestic violence. Even though the study evaluated men and women, the results for women were overwhelmingly striking.
It finds that women with symptoms of depression were 2.5 times more likely to have experienced domestic violence over their lifetimes than those in the general population, while those with anxiety disorders were more than 3.5 times more likely to have suffered domestic abuse. The extra risk grew to seven times more likely among those with post-traumatic stress disorder.
An analysis of more than 1 million Scandinavian women has shown that taking SSRIs during pregnancy may not increase the risk of stillbirth. This study could help revolutionize treating depression in pregnant women.
“From our study, we don’t find any reason to stop taking your medication, because untreated depression may be harmful for the pregnancy and the baby,” [Dr. Olof Stephansson, the lead author of the new report] told Reuters Health.
Finally, “gender identity disorder” has been removed from the DSM-V and has been replaced by “gender dysphoria,” a condition in which people are concerned about their gender identity. “Gender identity disorder” seemed to stigmatize gays, lesbians, and transgender individuals. The continuing inclusion of “gender dysphoria,” however, ensures that people suffering with gender identity disorder still have access to health care treatment. (In my opinion, the renaming of “gender identity disorder” to “gender dysphoria” is really a politically correct change. Homosexuality was removed from the DSM back in 1973.)
January 12, 2009 at 10:49 am (Bipolar Disorder, Medicine/Meds, Mental Health/Illness, Personal, Pregnancy, Suicide)
Tags: Adverse Effects, blurry vision, drug, fatigue, Lamictal, lamotrigine, medication, meds, placebo, Pregnancy, pregnant, psych drugs, psych meds, psychiatric mediation, psychiatric meds, psychotropic meds, psychotropics, side effects, withdrawal
My husband and I are talking about expanding our family. While that sounds all well and good, I just have one issue:
For most women, they think, “Well, I want a kid” and the most they have to do is probably get off birth control. Just finish off their contraceptives, maybe feel a little nauseous, and move forward with their plans.
(sigh) Not me. If I want to do this right, it might be a good 6 months or so before I can consider trying.
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May 23, 2008 at 5:16 pm (Antidepressants, Blogs, Loose Screws Mental Health News, Medicine/Meds, Mental Health/Illness, Military, Pregnancy, Suicide)
Tags: Adverse Effects, Antidepressants, birth defects, bravery, British Journal of Psychiatry, courageous, drugs, expecting, first trimester, Jordan Burnham, legislation, medication, meds, mental health, mental health parity, mental illness, moms, Montreal University, mothers, pasadena therapist, post-traumatic stress disorder, Pregnancy, pregnant, psych drugs, psych meds, PsychCentral, psychiatry, PTSD, Purple Heart, Purple Heart Award, senators, side effects, student, Suicide, suicide attempt, Ted Kennedy, VA, Veterans Administration, Wall Street Journal, women, WSJ
John Grohol at PsychCentral reports that the fate of the mental health parity bill is uncertain as its main champion, Sen. Ted Kennedy, takes a leave of absence to focus on treatment of his brain tumor. I echo John’s thoughts in hoping to see that other senators are willing to carry the torch and pass this important piece of legislation.
I came across a post from Kalea Chapman at pasadena therapist in which she linked to a WSJ article on whether veterans suffering from PTSD should be awarded the Purple Heart.
Supporters of awarding the Purple Heart to veterans with PTSD believe the move would reduce the stigma that surrounds the disorder and spur more soldiers and Marines to seek help without fear of limiting their careers.
Opponents argue that the Purple Heart should be reserved for physical injuries, as has been the case since the medal was reinstituted by Congress in 1932.
I side with the opponents. The Purple Heart should be awarded to be people who have visible evidence of bravery. With the rising number of PTSD prevalence, I’m afraid that the award would be handed out like candy. The rising number of veterans with PTSD on disability has caused enough of an issue that a Texas VA facility wanted mental health officials to stop diagnosing veterans with the condition.
Jordan Burnham, an 18-year-old student who survived a nine-story jump from a building, plans on walking at his graduation with the assistance of two canes. A family who used to attend my church knows this family and put him on my church’s prayer list. It’s a small world, after all.
Finally, it looks like expecting moms should have no fear of causing birth defects in their baby while taking antidepressants, according to a study being published in the British Journal of Psychiatry.
A research team from Montreal University studied more than 2000 pregnant women on antidepressants and discovered the drugs did not present any adverse effects. However, it sounds like they only oversaw the women while they were pregnant in their first trimester. I haven’t seen the actual study but it doesn’t seem to mention whether the women discontinued the antidepressants after the first trimester.
March 18, 2008 at 5:42 pm (Antipsychotics, Depression, Loose Screws Mental Health News, Medicine/Meds, Pharma, PPD, Pregnancy, Suicide)
Tags: AstraZeneca, big pharma, bill, bipolar, Bloomberg, clinical trial data, clinical trials, CPAP, creative, Depression, drugs, extended-release, FDA, GlaxoSmithKline, GSK, legislation, mania, medication, meds, mental health, mental illness, MHRA, MOTHERS Act, new moms, nondisclosure, paroxetine, patents, Paxil, pharmaceutical companies, poets, postpartum depression, postpartum psychosis, Pregnancy, pregnant, psych drugs, psych meds, quetiapine, scare tactics, Seroquel, Seroquel XR, Seroxat, sleep apnea, Suicide, treatment, UK, US, withholding, writers
I recently wrote about the MOTHERS Act and the unnecessary scare tactics surrounding it. A Dallas-Fort Worth TV station picked up on the story and provided a short one-sided view of the issue, continuing to purport that the bill is solely about drugging new moms. I don’t discount Ms. Philo’s terrible experience with her medication. In fact, I’d be against the act if its sole purpose was to force treatment on pregnant women – medicated or not. Again, I’d like to reiterate that the bill’s purpose is to educate moms about postpartum depression and postpartum psychosis – not to shove unnecessary pills down women’s throats.
If you have sleep apnea, your CPAP (Continuous Positive Airway Pressure) machine may alleviate depression symptoms. My husband has sleep apnea and hasn’t been able to use the CPAP machine because of sinus problems. When he doesn’t use it (he hasn’t for a while), he’s noticeably moodier and prone to depressive symptoms. But then again, anyone who doesn’t get good sleep for several days is pretty moody.
AstraZeneca (AZ) is going after Teva Pharmaceutical Industries and Novartis AG’s Sandoz unit after the two companies applied to make cheaper version of Seroquel available. AZ’s patent on Seroquel expires in 2011. The trial date for patent litigation is August 11. In the meantime, according to the Bloomberg report, the FDA is considering approval of Seroquel XR for bipolar depression and bipolar mania.
What is it about the U.K. that they seem to take pharma’s power more seriously than the U.S.? The UK Medicines and Healthcare products Regulatory Agency (MHRA) charged GlaxoSmithKline (GSK), the maker of Seroxat (Paxil in the U.S.), with not fully disclosing their clinical trial data that downplayed serious side effects such as increasing suicidal tendencies among those 18 years and younger. The MHRA also asserts that Seroxat didn’t alleviate depression as much as GSK’s initial data showed. GSK, of course, denied manipulating the data to show favorable results:
GSK denies withholding data, claiming the risks did not come to light until the results of nine studies were pooled.
The UK minister of public health, Dawn Primarilo, promised to address the issue of Big Pharma hiding negative clinical trial data.
“Notwithstanding the limitations that may exist in the law, pharmaceutical companies should disclose any information they have that would have a bearing on the protection of health,” she says.
In other news, I shouldn’t be a successful writer or novelist. The correlation between creative writers and suicide is ridiculously high. More than 70 well-known writers and poets have successfully committed suicide. How much more “unknown” writers and poets have as well?
(Image from Monthly Prescribing Reference)
March 15, 2008 at 8:02 am (Depression, Medicine/Meds, PPD, Pregnancy)
Tags: and Support for Postpartum Depression Act, anxiety, anxiety disorder, baby blues, big pharma, bill, birth, Congress, Depression, disorder, drugs, education, families, grants, legislation, medication, Melanie Blocker-Stokes Postpartum Depression Research and Care Act, mental disorder, mental health, mental illness, Mom's Opportunity to Access Health, moms, mood disorder, mothers, MOTHERS Act, new moms, NIH, NIMH, pharmaceuticals, postpartum depression, postpartum psychosis, PPD, PPP, Pregnancy, pregnant, psych drugs, psychotropic, research, symptoms, therapy, treatment, women
I stumbled upon Yankee Cowgirl’s blog that mentioned Congress is working on the MOTHERS (Mom’s Opportunity to Access Health, Education, Research, and Support for Postpartum Depression) Act which would “strongly encourage pregnant women into mental health programs – that means drugs – to combat even mild depression during or after giving birth.”
She links to a column written by Byron J. Richards on newswithviews.com. He writes:
The Mothers Act is pending legislation that will indoctrinate hundreds of thousands of mothers into taking dangerous psych drugs.
He goes on to slam Big Pharma about how they control Congress and how mothers don’t need psych drugs for a natural birth process.
The Mothers Act (S. 1375: Mom’s Opportunity to Access Health, Education, Research, and Support for Postpartum Depression Act) has the net affect of reclassifying the natural process of pregnancy and birth as a mental disorder that requires the use of unproven and extremely dangerous psychotropic medications (which can also easily harm the child).
These are some serious accusations. I got pretty riled up myself and decided to see what Congress said in the bill.
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