Loose Screws Mental Health News

An antipsychotic inhalation powder has been approved by the FDA for the treatment of agitation in adults with schizophrenia or bipolar I disorder. While loxapine (brand name: Adasuve) by Alexza Pharmaceuticals acts rapidly, the side effects include “bronchospasm and increased mortality in elderly patients with dementia-related psychosis,” according to Medscape. In case you don’t know, bronchospasm can lead to acute respiratory problems in people with lung disease, asthma, or COPD (chronic obstructive pulmonary disease).

Plans are for the drug to only be accessible through a medical facility with the ability to treat bronchospasms.

In related and somewhat interesting news, the Medscape article also notes that 3.2 million people in the U.S. are being treated for schizophrenia or bipolar I. “Of these, approximately 90% will develop agitation during the course of their illness.”

That’s an incredibly high number of people who develop agitation. Just sayin’.


According to an article in U.S. News & World Report, patients in a study dealing with depression seemed to have high levels of C-reactive protein (CRP), a marker for increased risk of heart and inflammatory disease. The lead researcher notes that “people with increased CRP have a two- to threefold risk of depression.” It is not clear whether CRP causes depression or is simply a sign of it. Increased levels of CRP tend to be seen in obese patients and those with chronic diseases.

“More than 21 million Americans suffer from depression, a leading cause of disability, according to Mental Health America.”

Note: the 2011 estimate of those residing in the U.S. stands at more than 311 million.


Depression is increasing among Japan’s public school teachers.

“A report by the Ministry of Education, Sports, Culture, Science and Technology shows that in 2011, around 5,200 public school teachers had to go on sick leave due to various mental illnesses, including severe depression.”

The Japan Daily Press article also notes:

“The study also highlights the fact that the main reason for the increasing depression is a school environment that puts too much workload and pressure on the teachers that they cannot have a healthy work-life balance anymore, much less deal with students, their guardians and the paper work that comes with all of these. (emphasis mine)

I recently finished a book by actor Tony Danza called I’d Like to Apologize to Every Teacher I Ever Had in which he chronicles his yearlong stint in Philadelphia’s inner city public school system. He echoes some of these sentiments as well. After trying to teach his students, he notes that it is difficult not to get involved in their personal lives as well. In the Epilogue, Danza writes:

“…I can only do so much. Where does teaching stop, and start? Where should it? I don’t really know. To engage my students, I found that I had to become engaged in their lives, their problems, and their futures. That connection was what made the job the most rewarding. Yet it was also the intensity of that involvement that, by the end of the year, had made the job of teaching so much tougher than I’d ever expected.”

It seems that Japan’s public school teachers are no different from American public school teachers.


Although 38 states require mental health background checks, only a quarter of states actually report their statistics to the federal NICS (National Instant Criminal Background Check System).


And surprise, according to a recent study, pot could lead to psychosis in teens or teens who smoke pot can later develop psychosis. I find it interesting that teens were actually evaluated after smoking pot.

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NICS the anti-depressants

In my Google alerts, I came upon a link to The Center for Science Writings at the Stevens Institute of Technology. John Horgan, a professor on the blog, received an e-mail from a former student commenting on the future of anti-depressant therapy:

Introducing “pharmacogenomics,” the latest and greatest addition to the ever-growing collection of pseudoscientific portmanteaus. According to a recent article in the New York Times written by Richard A. Friedman, M.D., there will soon be psychological medication that is custom-tailored to a patient’s DNA and genetic structure to ensure maximum effectiveness.

He makes his case with an example: his patient Laura. Laura was depressed, so Friedman gave her Lexapro, a common selective seratonin reuptake inhibitor (SSRI) anti-depressant. But Laura was still depressed, so he switched her to Zoloft, another SSRI. Still depressed, Laura switched to Wellbutrin, a non-SSRI anti-depressant. No dice. Dr. Friedman was frustrated; after three months he still couldn’t find an effective treatment for Laura. Then, Laura decided that since Prozac (also an SSRI) had helped her father with depression, she wanted to give it a shot. And voila, it worked!

If only Laura’s genes were able to reveal that Dr. Friedman should have prescribed Prozac, arguably the most well-known anti-depressant in America, from the very beginning, that would have saved a lot of hard, aggravating diagnosis work on everybody’s part.

But wait! There might be salvation on the horizon; according to Friedman it will soon be possible for doctors to analyze a patient’s unique genetic profile and prescribe the appropriate medicine so that time and money would no longer be wasted on the circuitous trial-and-error process of expert diagnoses.

No, what “melted away” Laura’s depression was good, old fashioned SSRI Prozac. But Friedman doesn’t see the contradiction. Instead, he claims that this new process of genetic-based medical treatments, “pharmacogenomics” will revolutionize the medicine, allow doctors to enhance their already astute diagnosing skills, and reduce the pharmaceutical industry to a withering dinosaur.

But what about Laura? What about the Prozac? Could it be that she was genetically predisposed to a specific brand of medicine? Are we all designed to respond to one drug label instead of another? If indeed that’s the case, there is only one logical conclusion to draw: God exists and He’s a Big Pharma shareholder.

Somehow, I’m not so convinced. — Suhas Sreedhar

I'm with Suhas. I skimmed Dr. Friedman's article and the whole process sounds weird. I think Laura probably – haha – psyched herself into thinking that Prozac would work since it worked for her dad.

While genes play a role in generational and familial health, I'm not completely convinced that psych meds would affect a father in the same way as it would affect his son or daughter across the board. Even if it really did work for Laura, I am skeptical that the method could be applied to any psychiatric patient. If a patient doesn't have any family, there we go with trial-and-error. Or we could just search our future FBI DNA mental health database and see if the patient matches up with anyone currently on meds.


Last week, Attorney General Alberto Gonzales called upon the remaining 27 states who don't report mental health files to the  NICS to do so. (That was an awful sentence.)

Speaking during a meeting of the nation's state attorneys general, Gonzales urged [states] to participate in the National Instant Criminal Background Check System, more popularly known as "NICS."

Then the article (linked to above) jumped to protecting the public from sex offenders:.

Gonzales also called for ideas on how to protect the public from convicted sex offenders.

Mental health experts, however, say Gonzales is overreacting. Sex offenders are less likely to repeat the same type of crime than other criminals, only about 13 percent within the first five years, said Dr. James Stark, former president of the Georgia Psychological Association.

"The whole country is in a predator panic. They've gone crazy," said Stark, who treats sexual disorders at the Marietta and Ellijay clinics of Psychological Forensic Associates.

"There are very few sex offenders who are actually dangerous," he said, adding that most of the 13,000 people on Georgia's registry of sex offenders are there for flashing, being a peeping Tom or having consensual sex with an underage girlfriend.

Maybe I'm overreacting. If a sex offender isn't dangerous, why is he or she a sex offender to begin with? Yup, peeping Toms don't ever turn into psychos. On that matter, try watching Alfred Hitchcock's movie, Psycho. (Please don't watch the remake. You'll be better off for it.)