November 21, 2011 at 1:35 pm (Anticonvulsants, Antipsychotics, Medicine/Meds)
Tags: Abilify, Aripiprazole, Lamictal, lamotrigine, medication, postamonth2011, psych drugs, side effects
Images from rxlist.com & drugs.com
Here’s a list of the side effects I’ve experienced recently taking Lamictal and Abilify (I can’t attribute any side effect to a specific drug since I am taking both):
1. Somnolence (I am sleepy within minutes after taking the drugs.)
3. Tremors (At night, I think I’m having convulsions but my husband says I don’t move.)
4. Delusions (I think I’m dying before I go to sleep.)
5. Disciplined sleep regimen (I wake up for the day when my alarm goes off. That’s consistently been 5:20 in the morning.)
6. Poor balance (This may be related to the dizziness and vertigo.)
I’ll add more to this list as I experience any additional side effects.
October 20, 2011 at 4:32 am (Antipsychotics, Bipolar Disorder, Depression, Medicine/Meds, Mental Health/Illness, Personal)
Tags: Abilify, Antidepressants, Aripiprazole, Ativan, Lamictal, lamotrigine, lorezepam, medication, psych meds, psychiatry
Images from rxlist.com & drugs.com
After 2 years of not being on medication, I am back to a daily regimen of lamotrigine (Lamictal) and aripiprazole (Abilify) with lorazepam (Ativan) as needed.
Many of you may know, or may not know, what I decided to taper off of medication so that I could get pregnant. Well, that hasn’t happened. And my thoughts got to a point where it became life and death again. I didn’t want to go back to the psych hospital so I asked my psychiatrist for help.
My psychiatrist (God bless him) is a very conservative psychiatrist. He was the one who helped me off of medication 2 years ago, and he’s the one titrating my dosages up now. Lamotrigine is for long-term maintenance of the bipolar disorder, aripiprazole is for short-term maintenance of bipolar disorder and SAD (seasonal affective disorder), and lorazepam assists with severe anxiety as needed. I started taking the medication four weeks ago, and I’m only on 50 mg of lamotrigine and 5 mg of Abilify. There will be no increase on Abilify and I titrate up on lamotrigine every 2 weeks. My next big jump is 100 mg.
My psychiatrist expects me to come off of aripiprazole within the next few months (hopefully by December). If not, I will have to get regular blood sugar and cholesterol tests performed. He will adjust all medications as necessary in the event that I am pregnant. He’s a great psychiatrist; he’s willing to work with me based on my situation rather than him throwing drugs at me. He allows me to have complete control over my treatment regimen, which is something I like and respect.
In the past, I may have come off as anti-medication, but really, I’m not. I advocate for use of medication in a necessary, responsible manner. In 2010, 253 million prescriptions were written for antidepressants.¹ (Keep in mind that the U.S. is estimated to have 307 million people in the country.²
That’s about 82.4% of the population taking antidepressants.) This is not responsible; this is too much. In the comments, people have rightly corrected me in the assumption that 1 person can get multiple prescriptions in a year; I failed to remember that.
Let’s assume a person is on 1 antidepressant (the majority of people take 1). Beginning in January, that person gets 5 refills for 30 days. By May, the person will need another 5 refills. Then another prescription is dispensed in October. That’s 3 prescriptions per person. Of course, this can vary depending on how often the doctor will see a patient so let’s generalize and say 5 prescriptions per person per year. My calculations for prescriptions per American mean that nearly 20 percent (about 17%) of the population is on antidepressants. Sure, it’s not my original ridiculous number of 82.4%, but I still think this is pretty high. (By the way, feel free to correct my stats in the comments if necessary; I don’t claim to be a math wizard.)
While I am not on an antidepressant, I am one of the millions of Americans who is on medication for mental illness. For 2 years, honestly, I’d forgotten I had anything relating to mental illness. It was nice to wake up and be myself without thinking about me plus bipolar disorder. Every morning and every evening, it’s now me plus bipolar disorder plus SAD plus anxiety. These are all real symptoms that need to be managed. I don’t want to be dependent on this medication forever, but I may have to. If it helps me manage my suicidal thoughts and function with people in life, then it’s worth it.
Your turn: What do you think about taking psychotropic medication? Do the symptoms outweigh the risks for you? What’s been your experience in taking (or not taking) psych meds?
1. Shirley S. Wang, “Antidepressants Given More Widely,” The Wall Street Journal. Published on August 4, 2011. Available at: http://online.wsj.com/article/SB10001424053111903885604576486294087849246.html. Accessed October 20, 2011.
2. Google Public Data Explorer. Population in the U.S. Last updated: July 28, 2011. Available at: http://www.google.com/publicdata/explore?ds=kf7tgg1uo9ude_&met_y=population&tdim=true&dl=en&hl=en&q=us+population. Accessed October 20, 2011.
September 14, 2009 at 7:46 pm (Anticonvulsants, Medicine/Meds, Personal)
Tags: Blogs, Lamictal, Lamictal withdrawal, lamotrigine, lamotrigine withdrawal, medication-free, weblogs
I’ve been off of Lamictal for the past month and a half thanks to a wonderful supportive mental health community of bloggers. I’ve replaced my Lamictal dosage with 1000 mg of Omega-3s derived from fish oil capsules. So far, so good. I haven’t felt suicidal although I do admit I’ve caught myself wanting to feel suicidal. Believe me when I say it’s significant progress to go from feeling suicidal to wanting to feel that way. (By the grace of God.) Special thanks goes to Gianna at Beyond Meds and Stephany at soulful sepulcher.
I haven’t blogged on mental health lately because I haven’t had much to blog about. Any attempt at regular blogging now is mostly done at This Journey Is My Own, which is distinctively personal, reflective, and an unabashedly Christian blog. I guess it can be considered a scrapbook. Thoughts and rambles flowing freely through the blog. I don’t have the attention span, dedication, and motivation to do anything like I used to with depression introspection. I’m not averse to updating this blog every now and then but the months with 80-some odd posts are now gone. The Quotes of the Week should continue updating through early 2010. Enjoy.
July 30, 2009 at 4:35 pm (Adverse Effects, Anticonvulsants, Medicine/Meds)
Tags: Anticonvulsants, Lamictal, Lamictal withdrawal, lamotrigine, lamotrigine withdrawal, med withdrawal, medication, medication withdrawal, meds, psychotropic, psychotropics
I’m at half the starting dose now. This means my body still has trace amounts of the drug but it’s so low that it’s not really effective. Here are the side effects I’ve been experiencing:
- Major brain fog
- Dizzy spells
- Lethargy (ie, no energy)
I’m also having trouble losing weight but I can’t say for sure if that’s attributable to the medication. If you were on Lamictal or are on Lamictal, what side effects have you experienced?
July 27, 2009 at 1:45 pm (Anticonvulsants, Medicine/Meds, Personal)
Tags: anticonvulsant, Anticonvulsants, GlaxoSmithKline, GSK, Lamictal, Lamictal withdrawal, lamotrigine, medication, medications, meds, psychotropics
We are now beginning our descent into Lamictal-free Airport. Please make sure your previous medications are stowed and that your side effects are fully behind you.
At this time, we request that you turn off all dependence on psychiatric devices.
Federal regulations require that you put your seat belt on in the event of any side effects. We hope you enjoyed your flight on GSK Airlines and hope to see your business again on a future medication.
Once again, ladies and gentlemen, we are now at 12.5 mg and are beginning our descent into Lamictal-free Airport.
(Photo source: Wired.com)
April 9, 2009 at 3:20 pm (Anticonvulsants, Antidepressants, Antipsychotics, Depression, Medicine/Meds, Mental Health/Illness, Personal, Schizophrenia)
Tags: Adverse Effects, Anticonvulsants, Antidepressants, big pharma, counseling, doctors, dopamine, drug withdrawal, drugs, escitalopram, Lamictal, lamotrigine, Lexapro, med withdrawal, medication, medication withdrawal, meds, neurotransmitters, paranoia, paranoid, patient, Pharma, pharma drugs, pharmaceutical, pharmaceutical companies, psych, psych drugs, psych meds, psychiatry, psychology, psychotropics, Schizophrenia, schizophrenic, serotonin, side effects, suicidal ideation, suicidal thoughts, Suicide, withdrawal
My brain isn’t functioning today quite honestly so my apologies if the following makes no sense whatsoever. It’s long and I ended up rambling.
Lately, I’ve been thinking about whether there are any benefits to using pharmaceutical drugs. I have blogger friends who are very much anti-pharmaceuticals anything, try to avoid drugs as much as possible but take them if necessary, or think pharmaceutical drugs are a Godsend.
I’m still trying to figure out where I stand.
Pharmaceutical companies are in the business of making money. It is not to their advantage to put out completely shoddy products that do not work. I’m sure many of them bury negative data and findings that do not shed a positive light on their drugs but if something works overall, they’ll put it out there. I don’t believe the doctors who are involved in these trials are all dirty, rotten sell-outs. Some of them are very well-meaning and honest who work to make these drugs as effective as possible. Call me naïve if you like but I just can’t bring myself to believe there are more greedy docs who skew results than there are those who are concerned with advancement.
I don’t think twice about popping Excedrin Migraine when I’ve got a painful, debilitating migraine; I have no problem taking naproxen (aka Aleve) when I’ve got menstrual cramps, and taking ibuprofen isn’t an issue if I have severe muscle pain. I don’t question the safety of these drugs. I’ve used them for so long, they’ve proven to be relatively safe for me (not everyone can tolerate those drugs) and efficacious. The safety risk of taking Excedrin Migraine sometimes outweighs the benefits of not taking it. (Note: I only speak of adults in terms of ingesting this kind of medication.I don’t believe developing bodies, such as youngsters, are able to handle medication that can significantly affect mood.)
When it comes to psych meds, I am not anti-medication. Psych meds should be taken on a case-by-case basis. There are some people who consider these meds to be a life-saver while others complain that it has made them miserable and worsened their lives. This is the gamble people take when choosing to ingest a psych med—most people don’t know that. Trouble is, most people don’t know when the stakes are high enough to take that risk.
I shouldn’t be in a position to judge anyone but when I hear people taking antidepressants based on circumstances—a job loss, failed relationship, loss of a life—I worry that it’s unnecessary. We are becoming a nation that is more reliant on “quick fixes” rather than developing coping mechanisms. It’s easier to pop a pill and dull your emotions than it is to face problems, tackle issues head on, and learn to work your way through it. Case in point: rising unemployment hasn’t slowed sales of antidepressants or sleeping pills.
- I have an aunt who was a violent paranoid-schizophrenic. She was placed in a mental institution and drugged up the wazoo. Now, she’s basically existing; the lights are on but no one’s home. The drugs have killed her. She’s alive but not really.
- My father was a non-violent paranoid-schizophrenic. It got to the point where we needed to medicate him to get him on track. The medication helped him to function “normally” but his thought processes and physical ability was significantly slowed. He once told me that he felt useless because my mother was busting her butt at work to pay for my college and he was basically an invalid because his mental illness had prevented him from being able to work. He died 4 months later. A few days after the funeral, my mom began to find his psych meds hidden all around the house. I often wonder if the drugs killed him.
- Another aunt (this is all on the paternal side of the family) also became a paranoid-schizophrenic. She was a brilliant woman who was basically reduced to moving from place to place to the point where she eventually became homeless and could not hold down a job. She disappeared for a while but during one cold winter, was found and brought into a homeless shelter. She was placed on meds and her cognitive functions returned despite the fact that her speech was sometimes garbled. She traveled the world, went on cruises and various excursions. The change was remarkable. Psych meds improved her life and saved her—the benefits of the drugs outweighed the side effects.
As I withdraw from Lamictal, I am curious to see who I am without this drug. Will my creative juices flow freely once again or are they now somewhat hindered? Will my cognitive functioning correct itself or will I forever suffer from problems? Will my short-term memory loss issues smooth out or will I still suffer from intermittent forgetfulness? I have some side effects that may remain with me for a while or perhaps forever (though I hope not) but seeing others fully recover after taking drugs for 10 times longer than I have gives me hope.
I feel the majority of my progress has come from intensive counseling and being infused with the truths as laid out in the Bible. I’d say 90% of my progress has been due to counseling. I give the meds 10%. You can tell I don’t place much stock in them. But they’ve helped to cut down on the mixed episodes.
So far, I haven’t had any suicidal thoughts are behaviors that are out of the ordinary. (Thank GOD.) I’ve been dealing with a mild depression but that stems from basing my worth based off of my career rather than any biological imbalances. The last time I suffered a severe depression, I was on Lexapro (if that tells you anything).
I’ve gotten a lot of resistance and concern from family members who question my decision to come off of the medication. They’ve seen a miraculous change in me and attribute it to being on meds. Meds aren’t a cure-all. They don’t see the counseling and shifting of thought processes going on that has helped me to develop coping mechanisms. Meds may help people “cope” but they don’t develop the tools needed to cope.
I’ve decided that I’ll probably give that Christian psychiatrist a call. My counselor recommended him and she said that he’s very neutral on meds and doesn’t shove them on anyone. I mentioned that I wasn’t sure if anyone would accept me as a patient only to lose me in the end—she insisted he wouldn’t mind. The intake cost is hefty but since I was able to temp a few days for my job this week—I’m not permanently returning, I can swing it.
Which brings me back to my position on psych meds: I said it earlier but I think it’s a case-by-case basis. In my personal life, I’ve seen the benefits outweigh the side effects and I’ve seen the side effects outweigh the benefits. And I’ve seen benefits (not necessarily beneficial) as a result of side effects. Psychiatry is the biggest medical guessing game of all medical specialties. There are no certainties, and there’s no one medication that works best for everyone. Pharmaceutical companies make it a point to put the disclaimer on the patient information sheet that they’re not exactly sure HOW these drugs work. All that stuff about serotonin, dopamine, and neurotransmitters is pure speculation when it comes to depression. You’ll have me convinced about chemical imbalances once I can get a MRI and blood test done. Until then, it’s all trial-and-error.
So if I do suffer from relapses while withdrawing from this medication and it gets to the point where I may need to be hospitalized, I’m not averse to remaining on the drug. Better to be alive and on a psych drug than dead because I was determined not to use it at risk to my safety. If I end up having to stay on the drug, the future of giving birth to children will seem a bit more uncertain.
March 26, 2009 at 10:44 am (Personal)
Tags: Adverse Effects, Lamictal, Lamictal withdrawal, lamotrigine, side effects
Last day on 100 mg, I think. I’ve been calling around to psychiatrists in my husband’s insurance network and it’s incredibly out of date despite the “Information updated on 3/22/2009” fine print. Someone’s not doing his or her job. I’m tired and don’t care to call around some more and deal with some nurse sounds pissed off for working in a “looney bin” and won’t give me a referral number.
So I’m left to my own devices for now and will be dropping down to 75 mg tomorrow. I’m just not sure I’ll find a psychiatrist who’s supportive enough to take me on as a patient only to lose me again in the end. Maybe the $400 2-hour intake with that Christian psychiatrist might be worth the money although I really balk at the cost.
In the meantime, I still am not sleeping well and have been sleeping all sorts of wacky hours. My job came back at me with an offer of more work but I declined this time. My job is to remain alert and catch errors and I am FAR from it. I don’t even feel safe driving right now. My comprehension level for anything is total and utter poop.
I’m simply alive and surviving. That’s all that can be asked from day to day, right? I’ll still make a few posts and my apologies in advance if they’re somewhat incoherent.
March 6, 2009 at 11:28 am (Adverse Effects, Blogs, Medicine/Meds, Suicide)
Tags: Adverse Effects, Effexor, Lamictal, lamotrigine, side effects, suicidal ideation, suicidal thoughts, Suicide, withdrawal, withdrawal symptoms
This is a great post from Ana on how she struggled with suicidal thoughts while tapering off of Effexor. She was a lot better about identifying this stuff than I’ve ever been. I’m linking to this because I want people to know that suicidal thoughts CAN be drug-induced. I’m well aware of that now coming off of Lamictal. No problems so far but I have struggled with it in the past when I tried to jump down from 200 mg to 150 mg.
March 5, 2009 at 4:14 pm (Personal)
Tags: Adverse Effects, drugs, Lamictal, lamotrigine, medication, meds, psych drugs, psych meds, side effects, withdrawal, withdrawal effects, withdrawal symptoms
I'm having the weirdest combo of side effects on this. I'm tired all the time, but I can't get to sleep easily no matter how hard I try. Then when I do sleep, it's craptastic and it feels like I never slept in the first place. Anyone else experienced this or heard of anyone who's experienced this? It's wearing me out and causing me to suffer from a lack of patience.
March 4, 2009 at 5:52 pm (Personal)
Tags: Adverse Effects, drugs, Lamictal, lamotrigine, medication, meds, psych drugs, psych meds, side effects, withdrawal, withdrawal symptoms
I'm down to 125 mg… I'm feeling sluggish and wiped out. I have what I call "body zaps" — basically I feel little prickles, like someone sticking a pin in my skin — that I find highly uncomfortable. (It's similar to feeling "brain zaps" or "brain shivers" throughout your body.) They mainly occur when I'm still, especially when I'm laying down in bed at night.
My sleeping schedule is also out of whack. While my body can be tired by midnight or 1 am, my brain simply will NOT shut off. My brain decides to shut down along with my body around 3 or 4 am from sheer exhaustion.
A few people have recommended I take melatonin to get back to a normal sleeping pattern, but I'm not sure whether that would be okay as I withdraw from the medication. Melatonin seems relatively harmless but right now, I can't tell what's normal with my body and what's not.
February 25, 2009 at 7:40 am (Personal)
Tags: cold, ill, Lamictal, lamotrigine, withdrawal
I'm most likely out of commission for the week. I traveled this past weekend and came down with this nasty cold. Along with tapering down on Lamictal, I'm feeling kind of spacey and out of it. Thanks to a good friend's advice, I'm holding off on tapering down some more until I'm feeling better. So right now, I can't tell whether I'm suffering from Lamictal withdrawal, the effects of a common cold, or a combination of the two.
Except for the blurry vision — I've had that since starting Lamictal and the withdrawal is making the difference much more, er, visible.
February 13, 2009 at 3:29 pm (Bipolar Disorder, Diagnoses, Medicine/Meds, Mental Health/Illness, Personal, Suicide)
Tags: Adverse Effects, drugs, Lamictal, Lamictal withdrawal, lamotrigine, lamotrigine withdrawal, medication, meds, prescription, psych drugs, psych meds, psychiatric medication, psychiatrist, psychotropics, side effects, taper off, wean off, withdrawal, withdrawal effects
I am officially joining the ranks of those who are facing the challenge of Lamictal withdrawal.
On Wednesday, I went to see my psychiatrist with a plan to come off of Lamictal:
- 150 mg for 3 months
- 100 mg for 3 months
- 75 mg for 3 months
- 50 mg for 3 months
- 25 mg for 3 months
- 12.5 mg (depending on whether my side effects on the 25 mg are bad)
I told him that my husband and I were looking to have a child sometime next year and that I’d like to taper off of Lamictal but was open to the possibility of getting back on it should I encounter severe suicidal ideation and mixed episodes. He warned me against it and thought it was a bad idea.
He proceeded to say that it’s a maintenance medication, I have a lifelong disorder, it won’t just go away, my symptoms would probably return, I have a higher risk of attempting suicide, blah blah blah — am I aware of all these risks?
He explained people with bipolar depression after coming off of meds can actually be worse, undergo severe depressive episodes, have more suicide attempts, and yadda yadda yadda. To sum it all up, I was risking my life just to get off of Lamictal.
My pdoc was trying to scare me into staying medicated.
He then added if I really wanted to come off of my meds, I could “just stop.”
WHAT?! My eyes flew open.
He stated he’d had patients who had stopped cold turkey without a problem. According to him, anticonvulsants don’t have severe withdrawal effects.
WHAT?! His advice just flies in the face of what most doctors recommend. In fact, quitting Lamictal immediately increases the risk of seizures, which is exactly what I’m afraid of.
Philip’s experience and Gianna’s experience along with the comments on each blog are proof that many people have experienced tremendous withdrawal effects from decreasing Lamictal’s dosage. In the past, I’ve quit Paxil and Lexapro cold turkey — both with not-so-good results to put it mildly.
I insisted that I wanted to come off of it slowly so he said I could just cut my 200 mg pills in half and jump down to 100 mg and stop after 2 weeks.
For real? Two weeks, doc? I had a plan that would take me over a year and you’re reducing it to a mere two weeks? On 100 mg dosage?
Again, I insisted that I wanted to take more time. He reluctantly wrote me a 30-day prescription for 100 mg and said since I was off the medication, I had no need to see him anymore. “Good luck,” he flatly told me.
When I came home after the appointment (and a bitching session to my husband), I remembered that I’d stashed a few 150 mg pills away sometime ago after I jumped back up to 200. So as of Wednesday, my arsenal included:
- A bottle of six 150 mg pills
- A bottle twenty-five 200 mg pills
- A prescription for thirty 100 mg pills
I dropped down to the 150 mg on Wednesday and have been doing all right so far. I intend to keep myself at 150 mg (cutting the 200 mg and the 100 mg in half) for at least 2 weeks, then drop down to 75 mg for 2 weeks and then 50 mg for 2 weeks. I’m most worried about coming off of the 25 mg. This is a way more accelerated plan that I hoped for but I’ve got to work with the cards that I’m dealt.
We’ll see what happens.
January 12, 2009 at 10:49 am (Bipolar Disorder, Medicine/Meds, Mental Health/Illness, Personal, Pregnancy, Suicide)
Tags: Adverse Effects, blurry vision, drug, fatigue, Lamictal, lamotrigine, medication, meds, placebo, Pregnancy, pregnant, psych drugs, psych meds, psychiatric mediation, psychiatric meds, psychotropic meds, psychotropics, side effects, withdrawal
My husband and I are talking about expanding our family. While that sounds all well and good, I just have one issue:
For most women, they think, “Well, I want a kid” and the most they have to do is probably get off birth control. Just finish off their contraceptives, maybe feel a little nauseous, and move forward with their plans.
(sigh) Not me. If I want to do this right, it might be a good 6 months or so before I can consider trying.
Read the rest of this entry »
September 26, 2008 at 9:52 am (Personal)
Tags: Lamictal, lamotrigine, update
There’s nothing much going on. My brain is mush and no matter how much sleep I get, I’m constantly tired. My husband is convinced that my fatigue stems from the generic Lamictal. The next time I see my psychiatrist, I’m likely going to go back to the brand Lamictal. It’s an additional $45 but if it helps this fatigue, then it’s worth it. I feel like such a zombie. Hence, why I haven’t really been blogging.
I’ve also been feeling lazy. I’m currently at this "I don’t care" stage where there’s a lot of things that I’m not obsessive about anymore so in a sense, that’s good.
So here is your requisite update. I’m still alive, still tired, but doing fine. (No suicidal thoughts, depression at bay.)
I’ll enjoy it while it lasts. Let me know how you are. I’ll make my blog rounds eventually.
August 5, 2008 at 11:34 am (Adverse Effects, Anticonvulsants, Medicine/Meds, Mental Health/Illness, Personal)
Tags: bipolar, Bipolar Disorder, cost, drugs, generic, generic equivalent, GlaxoSmithKline, GSK, health insurance, insurance, Lamictal, lamotrigine, medication, meds, money, pharmaceuticals, psych drugs, psych meds, psychotropic, Teva Pharmaceuticals
So much for Miss Up-on-Pharmaceuticals.
I’ve been paying so much attention to Pristiq that the very medication I take slipped out from right under my nose.
How did I find this out? It hit me where it hurt.
In the pockets, of course.
I went to CVS yesterday night for my Lamictal refill. Since I’ve been under my husband’s plan, we’ve been paying about $40 for the medication. So I nearly doubled over when the pharmacy cashier said $54.
I was in a bit of a foul mood about money anyway so the last thing I wanted to do was argue about the cost of my prescription that had jumped up by $14. (Which, in retrospect, I probably should have done because I could have saved $49 right there.)
I came home and made my husband’s day go from bad to worse. He flipped out and got on the phone with his insurance immediately. He said that the max he should pay on any medication is $50 so why was he paying $54 and why the cost rose so sharply.
“Well, sir, it’s because Lamictal has now gone generic and you’re paying the difference between the cost of the medication and the cost of the generic.”
Bob gets off the phone and goes straight to Google News to find out when Lamictal went generic.
According to MarketWatch.com, Teva Pharmaceuticals commenced shipment of lamotrigine tablets on July 22nd. So instead of either the pharmacist asking me if I wanted a generic version or the insurance company letting us know a generic version would be available (it would have saved them money), we ended up paying $49 more than necessary. It appears that Teva’s generic is AB-rated, which means that it has similar strength, bioequivalence, and efficacy. Overall, it likely shouldn’t be a problem if I go from Lamictal to lamotrigine. At least I hope not. We’ll see.
Mood rating: 5
April 29, 2008 at 6:19 pm (Medicine/Meds, Mental Health/Illness)
Tags: Abilify, alternative treatments, apiprazole, CLPsych, cognitive, cognitive functioning, cognitive impairment, drugs, Furious Seasons, Geodon, Lamictal, lamotrigine, medication, psych drugs, psych meds, psychotropics
Thank you, everyone, for your well-wishes and outpouring of support. I saw my psych today and he is adding 2-5 mg of Abilify to my medication regimen. He had me choose between Geodon and Abilify. Of course, I am hesitant to do this. Take a look at Philip’s post on Abilify and then take a look at CLPsych’s post about how Abilify performed against placebo. My psych pointed out that I did better on 200 mg of Lamictal but I distinctly remember feeling cognitive impairment on 200. The 150 seemed to work well for a while but I don’t know what’s happening. And to be quite honest, I’m always a little wary of alternative treatments even though I know they have helped so many people. I wonder if they are for me.
More thoughts soon…
March 6, 2008 at 11:12 am (Personal)
Tags: dosage, dose, freelancing, health care, health insurance, Lamictal, lamotrigine, medical insurance, medication
As of this past Monday, I currently own the title of "resident housewife." I made the big jump, at my husband's behest, and now find myself doing domestic things like housework and running errands. (I can't tell you how many times I washed dishes yesterday.) Oddly enough, I don't seem to mind except my feet hurt. I'd like a part-time job but the likelihood of obtaining a job where I wouldn't work weekends is highly unlikely. I have a friend, however, who's willing to pay me $10 an hour to help take care of her kids on Mondays, Wednesdays, and Fridays. She's currently having carpal tunnel problems so I'll likely take advantage of that offer whenever I can.
During the next coming weeks, I'm also going to try and freelance write. We'll see how that works out for me. I also wouldn't mind picking up some editing and proofreading jobs so I might have to re-interview with creative staffing services like Aquent and Boss Staffing. If anyone knows of any other creative staffing services like that in the Philadelphia area, please let me know. They specialize in placing people in "creative" jobs like editing, copy writing, proofreading, desktop publishing, web design, etc.
So that's my update. I can't promise multiple posts a day but I hope to write about mental health issues for a few publications so the potential for frequent posts and scouring other blogs for information in the next few weeks could be high. We'll see. I'm not sure about a market on writing about mental illness but it's one of the few topics I have a significant interest in.
As a result of leaving my job, the excellent medical insurance that covered my husband and I has expired. We'll be moving to his health care insurance (which isn't awful but not as great as mine was). After a cursory search, however, we noticed that my psychiatrist isn't included under his plan. I'm reluctant to go to another doctor because I've already established a rapport with my current one. He's allowed me to have control over my own treatment and dictate the medication that I choose to use. I'm afraid another psychiatrist would try to shove Abilify down my throat if I mention passing suicidal thoughts. A few months ago, I went down to 100 mg of Lamictal in an attempt to slowly come off of it. I've been decreasing my dosages by about 25-50 mg every three months. I had a recurrence of frequent suicidal thoughts so I upped my dosage back to 150 mg. I was hoping that perhaps I had tricked myself into feeling better in conjunction with my counseling, but my suicidal thoughts have significantly decreased on the increased dose. It never ceases to scare me how much medication influences my mind.
April 26, 2007 at 2:22 pm (Anticonvulsants, Blogs, Medicine/Meds)
Tags: bipolar, Bipolar Disorder, Lamictal, lamotrigine, mania, manic, manic episodes, medication, meds, mixed episodes, soulful sepulcher
“In its own way, the best patient group for Lamictal therapy is the bipolar II patient, a person with mild manias and severe depressions.” The side effects are also more tolerable than those of any bipolar drugs: little weight gain, lethargy, or nausea. “It’s the most interesting drug to come along since lithium,” says Ivan Goldberg. “Lamictal is hot shit.”
I found this on soulful sepulcher and have to admit – Lamictal has killed my manias. Since going up to 200 mg in January, I haven’t had a real manic episode – well, it’s really a mixed episode, but whatever. This makes me wonder if the Lamictal IS working; if I’ve tricked myself with a placebo; or if God is just being merciful to me. I try to convince myself with the last two. (Well, I find the latter to be absolutely true.)
Despite my pharma rantings, I have to agree: "Lamictal is hot shit."
March 12, 2007 at 2:00 pm (Adverse Effects, Blogs, Medicine/Meds)
Tags: drug interaction, drugs, Effexor, Lamictal, lamotrigine, medication, meds, psych meds, soulful sepulcher, venlafaxine
soulful sepulcher has a post up on drug interactions. You can find nearly all meds and find out the interactions as drugdigest.org. I did a search for lamotrigine (Lamictal) and venlafaxine (Effexor), which included interactions with food and alcohol and there were none. (That was a relief.) I’d encourage anyone on medication to do this search to make sure that multiple psych drugs are not interfering with each other.
March 8, 2007 at 1:10 am (Bipolar Disorder, Medicine/Meds, Mental Health/Illness, Pharma)
Tags: affiliations, bipolar, Bipolar Disorder, board, celexa, checklist, citalopram, clinical trials, consultant, Eli Lilly, escitalopram, gabapentin, GlaxoSmithKline, grants, GSK, Havidol, Hirschfeld, imipramine, Lamictal, lamotrigine, Lexapro, MDQ, member, Mood Disorder Questionnaire, paroxetine, Paxil, Pharma, pharmaceutical, pharmaceutical companies, pharmaceutical grants, questionnaire, quetiapine, Robert Hirschfeld, Schizophrenia, Seroquel, sertraline, UTMB, zoloft, Zyprexa
“GlaxoSmithKline, one of the world’s leading research-based pharmaceutical healthcare companies, is committed to improving the quality of human life by enabling people to do more, feel better, and live longer.”
OK, I’ll be honest. I can’t keep up with my own posts and have no idea whether or not I’ve posted on this yet. Judging from the fact that I still have this bp booklet, I’m going to guess not. If I have, then there’s more.
When my psychiatrist diagnosed me with bipolar disorder in November, he handed me a bunch of material: a mood tracker (PDF), an article touting the benefits of Seroquel, and a booklet titled, “Bipolar Disorder,” which refers the reader to www.1on1.health.com.
The booklet seems pretty harmless to a patient newly diagnosed with bipolar disorder:
“Highs and lows can be part of life. But, with bipolar disorder, they can be severe. You may feel too depressed to get out of bed one day. Soon after, you may feel full of energy. You may have normal times between the highs and lows. When people have mood symptoms, it’s more likely to be depression.
Mood swings can be hard to predict. But you may have warning signs. You may even learn what can trigger your symptoms. You’ll read about this and more in this booklet.
Bipolar disorder is complex. Doctors docn’t know what causes it. They know that genes play a role. The illness may be linked to brain chemicals. These chemicals can get out of balance.
There are treatments to help control the symptoms. Learn about your condition. Get help for it. This booklet is a good first step.”
Thank you, GlaxoSmithKline.
GSK, the provider of such psych drugs as Lamictal, Paxil, and Wellbutrin, issues a series of booklets for patients referring them to 1on1health.com. The topics include depression, anxiety disorders, epilepsy, type 2 diabetes mellitus, high cholesterol, among others. The tips seems pretty simple and straightforward:
“Health and lifestyle chances may trigger your symptoms. Some common changes are:
Not having a sleep schedule
Misusing alcohol or drugs
Stopping your medicine, or starting medicine for depression or another illness
Having thyroid or other health problems”
Then it gets into the general stuff about the difference between mania, depression and further clarifies what hypomania and mixed moods are. Then, the kicker follows:
“If you think you may have bipolar disorder, fill out the checklist on the next two pages. Share it with your doctor. He or she can use it to help diagnose you.”
Furious Seasons posted a link about a fake drug named Havidol (which I totally got suckered into because I skimmed the post and missed the “OK, it’s a gag” part), but the hilarity stems from similarly stupid (and vague) questions. I’ve put a screenshot of the PDF GSK provides on their Web site to the right. My issue is not so much with the questions necessarily, but with the lead-in to them:
“Has there been a time when...” [emphasis mine]
It doesn’t matter whether you were 3 years old or 46 years old, if you answered “yes” to more than one “there’s ever been a time when” question, guess what? You MAY qualify for bipolar disorder! A sampling:
Has there ever been a time when…
- You were easily angered that you shouted at people or started fights?
- You felt much more sure of yourself than usual?
- You talked or spoke much faster than usual?
- You were so easily distracted that you couldn’t focus?
- You had much more energy than usual?
- You were much more active or did many more things than usual?
- You were much more social than usual?
- You were much more interested in sex than usual?
Guaranteed everyone reading this said “yes” to at least TWO questions. If not, I question whether you’re breathing. (Sadly enough, this makes me realize how easy it was for me to get fooled by the phony Havidol quiz.)
The follow-up to the questions above asks, “If you checked YES to more than one of the questions above, have several of these things happened during the same period of time?” Then, “How much of a problem did any of these things cause you (like not being able to work, or having money or legal troubles)? Choose one[:]
- No problem
- Minor problem
- Moderate problem
- Serious problem”
The multiple choice question above may not matter. Answering some of the lead-in questions in the affirmative may qualify you for the disorder.
Here’s a nice little tidbit. The questionnaire was “adapted with permission from Robert M.A. Hirschfeld, M.D.” So as an uninformed patient reading this (which I was at the time), I’m thinking, “Oh, this must be legit since they got permission from a doctor to use this checklist.” There’s more than meets the eye here.
On the surface, Dr. Hirschfeld seems like an awesome doctor – and he very well may be. Dr Hirschfeld’s bio from the University of Texas Medical Branch at Galveston (UTMB) extols the “Professor and Chair” of its psychiatry deparment. He has history of working with various national organizations such as the National Depressive and Manic-Depressive Association, National Institute of Mental Health (NIMH), and National Alliance for Research on Schizophrenia and Depression (NARSAD). He’s written all kinds of articles and blah blah blah. He’s considered a leader in his research of bipolar disorder.
In fact, because Dr. Hirschfeld is so great, he’s a member of pharmaceutical boards and has acted as a consultant for pharmaceutical companies, according to ISI Highly Cited.com. Some of our favorite guys appear here: Pfizer, Wyeth, Abbott Labs., Bristol-Myers Squibb, Eli Lilly, Forest Labs, Janssen, and – lookee here! – GSK.
The duration of Dr. Hirschfeld’s affiliations with these pharmaceutical companies are unspecified. All other “appointments/affiliations” have assigned years, i.e. 1972-1977, 2001-Present. His consulting affiliations follow his internship in 1968-1969. It looks a bit misleading to follow the consulting jobs after, oh say, 1969, and not provide dates of when he became a consultant for all of these pharma companies. Toward the end of the document that I found, his affiliations from 1986-Present are listed with various boards, associations, journals, and a slew of pharmaceutical companies.
Hello, hello, hello. He is a MEMBER of the Zyprexa U.S. Bipolar Academic Advisory Board, the Celexa/Excitalopram [sic] Executive Advisory Board, the Lamictal National Advisory Board, and the Zoloft Advisory Board.
Humor me here. His clinical trials include:
- 1994 Paroxetine for Dysthymia (SmithKline Beecham)
- 1995-97 Several (I found five) double-blind studies on sertraline and imipramine in patients qualifying for the DSM-III definition of major depressive disorder
- 1996-98 Gabapentin therapy for bipolar patients
And the list, including mirtazapine, fluoxetine, venlafaxine, lamotrigine, goes on. You can also find the “grants” pharma companies gave to fund these clinical trials.
From 1997-2000, Hirschfeld received a $100K grant from Abbott Labs to develop “a new checklist for bipolar symptoms.” (I’m not sure what the old one was.) In 2001, he received a $142K grant for the “Bipolar Prevalence and Impact MDQ Project.”
I don’t even need to look MDQ up. It’s Mood Disorder Questionnaire. The grant came from GSK, who “adapted” the questionnaire with Hirschfeld’s “permission.” That sounds simply gravy.
To understand more about bipolar disorder, you can listen to the stories of Greg, Stuart and Leslie – all your classic bipolar cases and how medication and/or therapy has helped them so much. You can also watch the bipolar
disorder animation that regurgitates all the things that we’ve become skeptical about.
In the meantime, remember the instructions included in Seroquel’s safety information that no one reads (excuse the crappy “Paint” job):
March 2, 2007 at 11:49 am (Antipsychotics, Medicine/Meds, Pharma)
Tags: AstraZeneca, bipolar, Decision Resources, Eli Lilly, gold standard, Lamictal, lamotrigine, meds, Olanzapine, PR, psych meds, psychosis, quetiapine, Schizophrenia, Seroquel, Zyprexa
Whee for self-promotion!
“Eli Lilly’s Zyprexa Will Remain the Clinical Gold Standard for the Treatment of Schizophrenia Through 2015”
“Clinical Gold Standard,” huh?
I can’t bring anything new to the table on this. Maybe I’m wrong, but here I go:
“For almost three decades, Decision Resources has provided in-depth research on the trends, emerging developments, and market potential in various healthcare industry sectors. Our client base is diverse – including large pharmaceutical companies, emerging biotechnology concerns, financial services, managed care organizations, and medical device manufacturers who turn to Decision Resources to help shape their strategy and master their chosen markets.
The privately-owned company offers a rich array of research publications advisory services, and consulting that make it second to none for quality, analytical depth and insight. With access to almost 10,000 thought leaders, specialists, HMO formulary directors, and general practitioners, Decision Resources’ highly-credentialed analysts are able to reconcile real-world practice with hard numbers from the industry’s most respected data sources. The resulting analysis and insights drive business decisions and commercial success within the biopharmaceutical, managed care, medical device, and financial markets.”
Here’s my assessment, take it with a grain of salt: In an attempt to fight the decline in sales from the NYT-induced Zyprexa backlash, Eli Lilly has gone on the offensive and hired Decision Resources to reinvent its star medication.
Decision Resources (DR), a privately owned company (no hyphen if a modifier ends in “-ly”), has a client base that includes large pharmaceutical companies. Ta-da! Don’t get it?
Decision Resources is not a public company; hence, in addition to not receiving federal money, it doesn’t need to report its financial dealings to the SEC. Therefore, no publicly accessible financial records of DR’s clients. They haven’t said they are an “independent” organization. Perhaps this is implied. Whatever the case may be, DR gets paid by its client base to research their products and “help shape their strategy and master their chosen markets.”
This isn’t brain science; this is on their “About Us” section of their Web site. Therefore, if Eli Lilly turns to DR and pays them to – I like DR’s wording here – “shape their strategy and master their chosen markets,” then DR is essentially a PR loudspeaker letting everyone know that Zyprexa is the “clinical gold standard” for schizophrenia.
What a bunch of hooey.
Not too long ago, it seems that AstraZeneca (AZ) may have had DR engineer its new marketing strategy to give Seroquel a boost. Why not? Mental health media watchdogs are hatin’ on the atypical antipsychotics.
“According to a new report entitled Schizophrenia: Turning Physician Insight into Projected Patient Share, Zyprexa is superior in efficacy to all other current therapies, particularly on measures that are most important to prescribers, such as impact on global symptoms and responder rate.”
Holla at me if you’ve got your hands on that report mentioned above.
“In spite of scoring* less favorable than the other drugs in terms of safety and lower than risperidone in terms of delivery features, Zyprexa is the gold standard.”
OK – so it’s not safe and it doesn’t deliver as well as Risperdal – whatever that means – but Zyprexa is still “the gold standard”?
“This overall advantage for a drug with significant safety concerns highlights the importance of efficacy to prescribers.”
I want you to reread that: ” This overall advantage for a drug with significant safety concerns highlights the importance of efficacy to prescribers.” Let’s attempt to paraphrase this: The benefit of this potentially harmful drug shows the importance of how effective it is to those who receive the drug. Although Zyprexa has “significant safety concerns,” the drug works well enough for doctors to prescribe it to patients. Uh, no. Positives don’t outweigh the negatives. It was nice jargon for a second there, though. (If this is effed up enough for adults, why subject children to this crap?)
“The report also finds that the most commercially important emerging antipsychotics (Janssen’s Invega, Organon BioSciences’ asenapine, and Wyeth/Solvay/Lundbeck’s bifeprunox) score* lower than Zyprexa, indicating that Zyprexa will remain unsurpassed during Decision Resources’ forecast period.”
I know I’m doing a play-by-play but this is important. I need to find out how DR decided that Zyprexa would be the “gold standard” until 2015. (
What’s the significance of this year? Does EL’s patent on Zyprexa expire then? Nope, Eli Lilly’s patent on Zyprexa expires in 2011. Expect a similar molecularly structured olanzapine before then. Biolexapine?) So basically, in this report, DR’s conclusion is Zyprexa beats every other atypical antipsychotic for schizophrenia by far. Notice that AZ’s Seroquel (the soon-to-be “gold standard” of bipolar meds), an atypical also used for schizophrenia, is not listed. Not coincidence.
The little asterisk (*) next to the word “score” prompts me to wonder: Just how did they come up with these scores? Well, the asterisk tells me that I need to contact DR for the methodology behind the product scores. I just might. Then send it off to CL Psych or Furious Seasons to decipher the crap out of it.
Another thing to note on this PR:
“”Invega is a metabolite of risperidone and is likely to have efficacy similar to that of risperidone, which scored* slightly lower than Zyprexa overall,” said Nitasha Manchanda, Ph.D., analyst at Decision Resources. “Asenapine also lacks the differentiation to replace Zyprexa as the gold standard because it does not make as significant an impact on global symptoms, and bifeprunox is significantly inferior to Zyprexa in all primary efficacy measures and is not capable of surpassing Zyprexa.””
Dr. Manchanda, analyst for DR, pulled bifeprunox – not yet on the drug market – into the Zyprexa comparison and somehow was able to call it “significantly inferior to Zyprexa” with an incapability to “surpass” it. How many people have used bifeprunox, Ms. Manchanda? OK, now tell me how many people have used Zyprexa? And you’re telling me that a drug that hasn’t yet hit the market is “significantly inferior” to a drug that has been on the market for the past couple of years and has 1,200 lawsuits still pending in addition to the millions that have already been paid?
As for AZ, DR has determined that Seroquel will become the “gold standard” for bipolar medication by 2010, knocking Lamictal out of its current “gold standard” status. Like Furious Seasons, I had NO idea Lamictal was held up so highly for bipolar meds. Considering that lithium has always been the king of bipolar meds and treats both acute mania and depression better than Lamictal, I’m surprised to read this.
“According to the new DecisionBase report entitled Bipolar Depression: Turning Physician Insight into Projected Market Share, Seroquel’s advantages over Lamictal include the more profound effect on depressive symptoms seen in short-term trials.”
My doctor precribed Lamictal to me for management of depressive symptoms in bipolar disorder. He conversely prescribed Seroquel for mania (and to help me get sleep). Getting back to the short-term trials, Lamictal was tested for 18 months for long-term management of bipolar disorder. Seroquel, however, was tested for 8 weeks. Effective for the short-term? Perhaps. But most patients on atypicals take them long-term. And that’s precisely where Seroquel fails.
“The drug’s efficacy on this measure differentiates it from other therapies, according to thought-leading psychiatrists, and the importance assigned to this measure by prescribing psychiatrists drives Seroquel’s product score above Lamictal’s.*”
According to thought-leading psychiatrists who probably function as consultants and analysts for “large pharmaceutical companies.” Seroquel may have the potential to sell more than Lamictal by 2010 – if this is what DR’s gauging. However, it seems like DR is trying to push Seroquel, not just as a better market share, but as a better product. In this “report,” DR also fails to compare Seroquel’s efficacy to Zyprexa’s. What a convenient absence for a product used for psychosis in bipolar disorder.
(ignore any spelling errors in this post. it’s late and i bumped my forehead against the edge of a car door in the rain. ouch.)
January 22, 2007 at 9:48 am (Adverse Effects, Antipsychotics, Medicine/Meds, News, Personal)
Tags: Dawdy, Effexor XR, escitalopram, Forest Pharmaceuticals, Furious Seasons, Lamictal, lamotrigine, Lexapro, paroxetine, Paxil, quell, quetiapine, Seroquel, Susie Q, venlafaxine, weight change, weight gain, weight managment
Furious Seasons has blogged about Seroquel (quetiapine) in the past and he recently posted on Seroquel abuse in an Ohio prison. Apparently, inmates have been snorting the atypical antipsychotic, also known in slang terms as “quell” or “Susie-Q.” Excerpt from Furious Seasons:
“Second, we all know that Seroquel is regularly handed out to bipolars and depressives and people with anxiety in order to address insomnia, as opposed to the kind of underlying psychosis/mania issues you’d expect it to be used for. PCPs hand it out this way and so do psychiatrists. What I have noticed among friends who’ve been given Seroquel for sleep issues is that they end up, over a few months time, needing more and more of the drug in order to get an effect. Or, put another way, people keep complaining of problems with sleep despite taking, say, 300 mgs. of Seroquel and their doctor will keep upping the dose to get the desired effect. As a result, I have seen people with very mild bipolar disorder wind up taking 800 mgs. of Seroquel a day–that’s roughly the same that a schizophrenic in a state hospital would get–and still they get no results, aside from putting on tons of weight. I have heard this from other readers of this blog as well.”
My aunt, who works in the psych wing of a hospital, warned me that she’s seen patients on Seroquel gain weight. A man I met at my Bipolar and Depression Alliance Group last night gained 60 lbs since taking Seroquel. I can’t image that everyone who takes Seroquel overeats to a point of obesity and leads a sedentary lifestyle. I have a random theory that Seroquel signficantly slows a person’s metabolism down to the point where it is difficult for a person to lose weight.
Read the rest of this entry »
January 18, 2007 at 9:36 am (Adverse Effects, Antipsychotics, Bipolar Disorder, Medicine/Meds, Pharma)
Tags: Andrew J. Cutler M.D., article, AstraZeneca, atypical antipsychotic, AZ, big pharma, bipolar, bipolar depression, Bipolar Disorder, bipolar pill, Clinical Psychiatry News, clinical trial, CORE Research, Dawdy, Furious Seasons, Lamictal, lamotrigine, lithium, Patient Safety Information, pharmaceutical research, psychopharmacology, quetiapine, Seroquel, side effects, weight gain, weight loss, wikipedia
[UPDATE: I had some funky issues with my table. It should be fixed now. Sorry about that.]
The first time I visited my psychiatrist for my initial evaluation, he gave me the option of choosing one of three medications: Seroquel, Lithium, or Lamictal. He handed me information about Seroquel and Lamictal. I did some research on both meds (lithium was out of the question because I don’t have time to get my blood checked constantly) and Lamictal sounded like a way better deal than Seroquel. I found mental health blog Furious Seasons (probably via The Trouble With Spikol) and read numerous posts on Seroquel’s adverse effects and all the good stuff AstraZeneca doesn’t tell anyone. From Philip Dawdy’s “Seroquel, The Bipolar Pill?” post, here’s what stood out to me:
“He told her that he didn’t think Seroquel worked benignly for patients and that the increased blood-sugar levels and cholesterol levels associated with its use were unacceptable to him. She broke out a recent paper which claimed that there were no metabolic syndrome problems with Seroquel.”
The post got me thinking. One of the materials I received from my psychiatrist was an article on how Seroquel seems to help the depressive part of bipolar disorder. He had a stack of these articles. My guess is not that he’s an overzealous reader of various newspapers but received the glowing article from – you got it! – a pharma rep. The article was taken from the August 2005 issue of Clinical Psychiatry News. (NOTE: I received the article in November 2006.)
Clinical Psychiatry News’ publication goals:
“Clinical Psychiatry News is an independent newspaper that provides the practicing psychiatrist with timely and relevant news and commentary about clinical developments in the field and about the impact of health care policy on the specialty and the physician’s practice.”
Good thing they didn’t say objectively.
I don’t know much about ClinPsych’s reputation and whether they are generally a good paper that reports things objectively. However, the article, “Atypical Quetiapine Appears Effective for Bipolar Depression,” reads like a press release. I’m not happy about receiving (practically) PR material from my doctor when trying to make an unbiased decision.
The article’s lede:
“The atypical antipsychotic quetiapine led to significantly greater reductions in bipolar depression than did placebo within the first week of treatment and throughout an 8-week randomized, controlled study of 511 patients, Andrew J. Cutler, M.D., said.”
Dr. Cutler? Who IS Dr. Cutler? No research necessary; look no further than the article itself:
“The differences between the placebo group and each quetiapine group were significant at each weekly assessment, said Dr. Cutler of the University of South Florida, Tampa. He is a speaker and consultant for, and has received research grants from, the company that makes quetiapine: AstraZeneca.”
At least they disclosed his financial affiliations.
It is also worth noting that Dr. Cutler also founded a clinical research company, CORE Research, which runs many of the clinical trials that he’s involved in. CORE Research’s background details:
“CORE Research, Inc. is a private research company with three offices in the Central Florida area. CORE specializes in pharmaceutical research and psychopharmacology for mental illnesses such as Bipolar Disorder, Depression, Anxiety, Schizophrenia, Attention Deficit Disorder, and Insomnia.”
Private + Pharmaceutical research + Psychopharmacology = Funding from Big Pharma Companies
I sound like I’m touting some grand conspiracy theory. (OK, maybe I am.) CORE’s background bio makes the company sound objective and unaffiliated, which isn’t the case. If Dr. Cutler has “received research grants from” not only AstraZeneca, but other companies, it’s in his best interest to make sure that their pharmaceutical products turn out OK. Namely in the interest of AZ – remember: he’s a consultant for them.
How can I expect to make a decision about which medication to take (remember it’s between Lamictal and Seroquel now) based on promotional materials from pharm companies and – oh – an article touting the benefits of Seroquel with quotes only from the study’s lead author who is paid to say good things about the company’s products?
Then how did I decide on Lamictal over Seroquel? Wikipedia‘s outline of each medication’s side effects, of course, in addition to other materials. (Don’t EVER overlook the Patient Safety Information of any medication. Unless you’re reading about the molecular structure – ignore that.)
|Lamictal (lamotrigine) side effects
||Seroquel (quetiapine) side effects
|Major weight loss
||Memory problems (i.e. anterograde amnesia)
||Abnormal liver tests
|Lack of coordination
||Substantial weight gain
||Stuffy nose feeling
|Rash (Stevens-Johnson syndrome) [uncommon in adults]
||Neuroleptic malignant syndrome [rare]
|Binds to melanin-containing tissues (i.e. iris of the eye)
||Tardive dyskinesia [rare]
Not that Lamictal’s side effects looked like a walk in the park, but considering that I’d already had awful trouble with weight gain on Paxil and Lexapro – nearly 50 lbs. – Seroquel was a serious no-go on my part. That and I don’t mind major weight loss from Lamictal. (Although I have been told Lamictal has no effect on weight.) Below is a copy of the article I received from my psychiatrist or you can just go and read the archived full text at Clinical Psychiatry News.
January 16, 2007 at 4:35 pm (Anticonvulsants, Antipsychotics, Bipolar Disorder, Celebrities, Depression, Loose Screws Mental Health News, Medicine/Meds, Mental Health/Illness, Pharma, PTSD)
Tags: Antidepressants, bipolar, Bipolar Disorder, bp magazine, clinical psych, Depression, disabilities, Eli Lilly, kelly osbourne, lamotrigine, marriages, mental health, mental illness, News, pets, psychiatric, psychiatry, Spikol, zyprexafacts.com
Yeah – the copy editor in me wants to try “Loose Screws News.” For now.
Clinical Psychology and Psychiatry is among many of my favorite blogs to read. In this particular post, he rips on Eli Lilly’s zyprexafacts.com, which was set up in response to NYT articles that alleged Lilly drug reps pushed Zyprexa to physicians for off-label uses. I hope to just have a stupid ol’ time and rip on each Eli Lilly press release in response to each NYT article, but we’ll see what happens. I’ve already got one lined up with notes scribbled on the printout; I just need to transfer it into electronic form. (Oh, the joys of being a transit commuter.)
Liz Spikol linked to an article originally published in bp magazine about how difficult marriages are when one spouse suffers from bipolar disorder. The saddest statistic I’ve ever read:
“In the United States and Canada, at least 40 percent of all marriages fail. But the statistics for marriages involving a person who has bipolar disorder are especially sobering—an estimated 90 percent of these end in divorce, according to a November 2003 article, ‘Managing Bipolar Disorder,’ in Psychology Today.”
Um, joy considering that I’m I suffer from bipolar and have been married for just over a year now. This strikes incredible fear in my heart. It’s not that we don’t love and care for each other, but I can only imagine how much a spouse who doesn’t suffer from bipd can take. I hate to say it, but I keep waiting for my husband to walk out on me. Not because I’m pessimistic (OK, I am, but that’s beside the point), but because I fear that he’ll reach a point where he’ll say, “I can’t take anymore of this! I’ve dealt with this for 10 years and nothing’s changed, nothing’s getting better. I’m sorry, but I can’t be married to you and deal with this anymore.” Just waiting.
Retarded celebrity story of the day: Kelly Osborne suffers from depression because she’s so privileged. But hey! — she’ll pose for Playboy and get photoshopped so she can feel better. *gags*
If you’re mentally ill and fired for it, don’t bother suing. It looks like the mentally ill don’t have a case unless there’s a physical illness to somehow “prove” it:
“Sixteen years after Congress enacted the Americans with Disabilities Act (ADA), people with psychiatric disabilities are faring worse in court cases against employers for discrimination than are people with physical disabilities, researchers have found in a national study.
‘People with psychiatric disabilities were less likely to receive a monetary award or job-related benefit, more likely to feel as though they were not treated fairly during the legal proceedings and more likely to believe they received less respect in court,’ said Jeffrey Swanson, Ph.D., a study investigator and an associate professor of psychiatry at Duke University Medical Center.”
I’m not sure how to solve this problem. Psychiatric disabilities are less tangible and harder to prove than a physical disability. It’s easier to wage war against a company if you suffer from a bad back vs. if you suffer from depression. (Whether or not the bad back is a fictional illness is up to you.)
Another oy moment. (The Long Islander in me is coming back full force.) Got a pet that’s misbehaving? Put him or her on an antidepressant. Double oy.
New Zealand is being introduced to lamotrigine (trade name Lamictal in the U.S.). Good luck, bipolar New Zealanders. Best wishes.
And finally, a study has discovered that about half of patients who suffer from some kind of severe burn suffer from clinical depression. (Shouldn’t someone diagnose this as PTSD? That’s pretty traumatic, if you ask me.) While the finding isn’t surprising, the study highlights the need not only to treat the physical ailment, but also to address the mental healing necessary to overcome stress from the injury.
January 9, 2007 at 3:32 pm (Adverse Effects, Antidepressants, Depression, Medicine/Meds, Personal)
Tags: about.com, bipolar, Bipolar Disorder, brain, brain shivers, brain shocks, Depression, discontinuation, dizziness, Effexor, Effexor XR, electric shocks, electrick shock sensations, Fluoxetine, Lamictal, lamotrigine, light-headedness, mania, manic, manic-depressive, medication, meds, paroxetine, Paxil, Prozac, psych meds, psychiatrist, quetiapine, Schimelpfening, sensory disturbances, Seroquel, side effects, symptoms, taper off, venlafaxine, vertigo, weird sensation, withdrawal, withdrawal symptoms
Work has got me busy, folks, so posts may drop significantly in the next coming days/months. Possibly through April or May. (I’ll probably have one of those work days when I end up doing more blogging than working. It happens every now and then.) But don’t be surprised if Saturday quotes, Wednesday puppies, and Sunday stats are what pops up each week. I’ve got many of those backlogged through April. I’ll try to backlog some other posts on bipolar disorder and depression for the coming weeks and quickly blog on anything that’s timely.
In the meantime, I had to take a sick day today. It’s my third day off of the Effexor and I’m having some weird side effects (see Case 1: Standard Dose under the link). Whenever I turn or move too quickly (consider your “natural” body turn), I “kind of” see stars and the whole world slightly spins beyond my field of vision for about 3 seconds before coming back into focus. After doing some light research on the side effects of venlafaxine (Effexor’s generic name), I’ve found out that side effects can incude vertigo, dizziness, light-headedness (associated with dizziness), and something called “brain shivers,” which are a form of electric shock sensations. You know that feeling when you get an electric shock from somebody? Yeah, imagine feeling that throughout your whole body. Precisely; not a good feeling. Nancy Schimelpfening, blogger for depression.about.com, found a newsgroup posting on the brain shiver effect, mainly associated with venlafaxine:
It happens to me if I turn my head quickly, or if I stop suddenly, or in general with sudden motion. They’re worse if I’m nervous.
i’ve seen them described as feeling as though your brain keeps going when you turn your head. that doesn’t seem quite adequate to me. it’s more like this:
you turn your head (or your whole body — this happens to me if i whirl around too quickly as i’m taking the stairs. what. doesn’t everyone whirl on the stairs…?), but your brain *stays put* for a micro second, then tries to catch up but only in a stuttering, stopstart motion, accompanied by a staccato ‘zzt zzt zzt’ with each stop. the ‘zzt’ you can feel in your head, an electric sort of vertigo, and it often reverberates in your hands and fingers. some folks feel it in their toes; i haven’t yet.
sometimes your brain overshoots and comes strobing back, then overshoots again.. this all unfolds in just a second or two.
these days i endeavor to go around corners all smooth slow and steadylike. helps to reduce the number of brain shivers per day
Yeah, that’s me. It’s hard to explain to someone who’s never felt it. I got this feeling after not taking Paxil for three days too. The effects eventually wore off, but it was such a weird feeling.
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December 18, 2006 at 1:44 pm (Depression, Medicine/Meds, Mental Health/Illness, News, Personal, Pharma)
Tags: bipolar, Bipolar Disorder, celexa, dementia, Depression, dosage, drug reps, Effexor, Effexor XR, elderly, Eli Lilly, escitalopram, Lamictal, lamotrigine, Lexapro, Lilly, lithium, medication, meds, mental health, mental illness, Olanzapine, paroxetine, patients, Paxil, PCPs, prescribing, prescriptions, primary care physicians, psych hospital, psych meds, psychiatrists, psychosis, quetiapine, Schizophrenia, seniors, Seroquel, suicidal ideation, suicidal thoughts, Suicide, venlafaxine, Zyprexa
Eli Lilly’s actions continue to be appalling.
Apart from trying to hide the fact that Zyprexa induces weight gain, diabetes, and hyperglycemia, they also had sales reps encourage primary care physicians to prescribe Zyprexa for patients who did not have schizophrenia or bipolar disorder (basically off-label usage).
It seems that Lilly told marketing reps to suggest Zyprexa for dementia in the elderly. Lilly denies this, of course, since olanzapine (Zyprexa’s generic name) is not approved for that kind of use since it increases the risk of death in seniors with psychosis associated with dementia. Lilly also attempted to market olanzapine to patients with mild bipolar disorder who suffer mainly from depression. (In actuality, Zyprexa is approved to treat those who suffer from mania.)
This issue with Eli Lilly delves into precisely why I am against PCPs prescribing psychiatric medicines. Primary care physicians don’t know enough about the various psychiatric conditions to prescribe the appropriate kind of medication. This type of prescription should be left to specialists like psychiatrists. PCPs should focus on the things they deal with on a daily basis that no one else can take care of: the common cold, the flu, annual physical, etc. It should be the job of the PCP to refer a patient to a psychiatrist should they present symptoms of mental illness (depression, schizophrenia, etc.). I have been burned by having a PCP prescribe antidepressants for me and as a result, attributed my horrible experience with drugs to that.
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