Neurontin: Pfizer and Eli Lilly share a common history

My mother-in-law was telling me yesterday about how her hairdresser’s daughter has been diagnosed bipolar with OCD characteristics. She says her daughter’s on “Neo-something” – she couldn’t quite remember the name.

I racked my brain for a bipolar med name that began with “n.” Nothing really came to mind except for neurontin. I told myself, “No, that can’t be right. Isn’t that associated with VNS?”

Nope; Neurontin really is a medication associated with bipolar disorder. Neurontin’s generic name is gabapentin.

Neurontin (gabapentin)

Continue reading “Neurontin: Pfizer and Eli Lilly share a common history”

Loose Screws Mental Health News

Yeah – the copy editor in me wants to try “Loose Screws News.” For now.

Clinical Psychology and Psychiatry is among many of my favorite blogs to read. In this particular post, he rips on Eli Lilly’s zyprexafacts.com, which was set up in response to NYT articles that alleged Lilly drug reps pushed Zyprexa to physicians for off-label uses. I hope to just have a stupid ol’ time and rip on each Eli Lilly press release in response to each NYT article, but we’ll see what happens. I’ve already got one lined up with notes scribbled on the printout; I just need to transfer it into electronic form. (Oh, the joys of being a transit commuter.)

Liz Spikol linked to an article originally published in bp magazine about how difficult marriages are when one spouse suffers from bipolar disorder. The saddest statistic I’ve ever read:

“In the United States and Canada, at least 40 percent of all marriages fail. But the statistics for marriages involving a person who has bipolar disorder are especially sobering—an estimated 90 percent of these end in divorce, according to a November 2003 article, ‘Managing Bipolar Disorder,’ in Psychology Today.”

Um, joy considering that I’m I suffer from bipolar and have been married for just over a year now. This strikes incredible fear in my heart. It’s not that we don’t love and care for each other, but I can only imagine how much a spouse who doesn’t suffer from bipd can take. I hate to say it, but I keep waiting for my husband to walk out on me. Not because I’m pessimistic (OK, I am, but that’s beside the point), but because I fear that he’ll reach a point where he’ll say, “I can’t take anymore of this! I’ve dealt with this for 10 years and nothing’s changed, nothing’s getting better. I’m sorry, but I can’t be married to you and deal with this anymore.” Just waiting.

Kelly Osborne Retarded celebrity story of the day: Kelly Osborne suffers from depression because she’s so privileged. But hey! — she’ll pose for Playboy and get photoshopped so she can feel better. *gags*

If you’re mentally ill and fired for it, don’t bother suing. It looks like the mentally ill don’t have a case unless there’s a physical illness to somehow “prove” it:

“Sixteen years after Congress enacted the Americans with Disabilities Act (ADA), people with psychiatric disabilities are faring worse in court cases against employers for discrimination than are people with physical disabilities, researchers have found in a national study.

‘People with psychiatric disabilities were less likely to receive a monetary award or job-related benefit, more likely to feel as though they were not treated fairly during the legal proceedings and more likely to believe they received less respect in court,’ said Jeffrey Swanson, Ph.D., a study investigator and an associate professor of psychiatry at Duke University Medical Center.”

I’m not sure how to solve this problem. Psychiatric disabilities are less tangible and harder to prove than a physical disability. It’s easier to wage war against a company if you suffer from a bad back vs. if you suffer from depression. (Whether or not the bad back is a fictional illness is up to you.)

Another oy moment. (The Long Islander in me is coming back full force.) Got a pet that’s misbehaving? Put him or her on an antidepressant. Double oy.

New Zealand is being introduced to lamotrigine (trade name Lamictal in the U.S.). Good luck, bipolar New Zealanders. Best wishes.

And finally, a study has discovered that about half of patients who suffer from some kind of severe burn suffer from clinical depression. (Shouldn’t someone diagnose this as PTSD? That’s pretty traumatic, if you ask me.) While the finding isn’t surprising, the study highlights the need not only to treat the physical ailment, but also to address the mental healing necessary to overcome stress from the injury.

Drugging of the Bipolar Mind

From Philip Dawdy's article, "The Drugging of the American Mind," originally published in the Seattle Weekly:

"Classically, the disorder is treated with a mood stabilizer. Lithium was long the gold standard. In recent years, there has been a shift to anticonvulsants like Depakote or Lamictal. Often, bipolars are also given an antidepressant like Paxil or Effexor to deal with bouts of depression. Until 2000, the mood stabilizer plus antidepressant approach was essentially the state-of-the-art treatment. It just doesn't knock down symptoms forever.

Bipolars can "break through" these meds and wind up having acute episodes of rage or suicidal depression."

Wow. The article was published just over a year ago and it describes me to a T today. Well done, Mr. Dawdy, for seeing my future.

"This is an awkward time for mental- health experts, researchers, and advocates. This month, a peer-reviewed academic paper was published on the Public Library of Science Web site pointing out that researchers still have not proved the serotonin-imbalance-in-the-brain hypothesis of depression. What proof there is, the authors claim, is mostly circumstantial. Two weeks ago, The Wall Street Journal ran an article covering the same points in relation to antidepressants."

That was in November 2005. It's good to know that I'm not the only one that sees the neurotransmitter link to mental illness as merely a hypothesis and NOT fact. Many people don't know that at the bottom of each psych med Web site and in the important safety information sheet that comes with a psych med basically says, "We're not exactly sure how this works." Well, gee, thanks for allowing me to take a risk about something you're not even sure about!

Praise to Dawdy, amazing blogger for Furious Seaons,  for uncovering much of this information that most people in America don't want to cover or are too lazy to educate themselves about.

SSRIs

Selective Serotonin Reuptake Inhibitors
(from monstersandcritics.com)

  • present fewer side effects than their predecessors
  • less likely to be lethal even in large quantities (important for someone who may be suicidal)
  • the
    Federal Drug Administration (FDA) wants SSRI dosage minimized to
    decrease risk of overdosage and close monitoring of younger patients on
    the drug
  • suicide rates overall have declined since SSRI market introduction
  • side effects ma include insomnia, rashes, headaches, joint and muscle pain, upset stomach, nausea or diarrhea
  • mixed with painkillers, SSRIs can pave the way for stomach or uterine bleeding

In the Hindustan Times,
an article ran on a girl who committed suicide because she had not
received the grades she had hoped on a test. One highlight (if you can
consider it that) of reading world news is that they'll report local
suicides more often than U.S. media. The HT story reminds me that there
is no excuse too small or too big for people to commit suicide.

Indian focus recently has been on eliminating suicide scenes from films to prevent copycat cases. In one incident,
a mother dragged her four kids out o the train tracks to die with her.
Two of them were able to escape and survive before a train pummeled the
rest of the family to death.

Ireland is also tackling suicide – they've set a 20 percent reduction target by the year 2016. A published report notes that suicide rates are rising in males younger than 35 and in females under 25. Wisconsin
is battling youth suicide, much like Ireland, and hopes to reduce its
current rate of one young adult committing suicide per week by 10
percent. No time frame for the reduction has been set.

An anti-seizure drug, Neurontin, is being blamed for nearly 300 suicides nationwide.
It is the best-selling anticonvulsant medicine in the U.S. and Pfizer –
Neurontin's maker – posted profits of more than $2.6 billion in 2004.
The FDA has not pushed to have Neurontin taken off the market, but in
2005, simply ordered a review. The results have never been made public
as of today.

A man who killed himself after being turned away from the hospital has drawn worldwide attention to the inadequacies of Australia's mental health system. Although I'm sure similar events have occured in the U.S., it likely does not get widespread coverage.